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Sickness absence among patients with chronic pain in Swedish specialist healthcare
(2021-12-20)
Background: Chronic pain beyond three months is a global public health problem. Every third adult suffers from a chronic pain condition, resulting in a socioeconomic burden that corresponds to 3-10% of gross domestic product ...
Single cell studies of human T cell function with applications for HIV-1
(2016-04-18)
T cells are one of the body’s main defenses against viruses and cancers and are therefore considered to play a major role in immunotherapies after stem cell transplantation and in HIV-1 vaccine and cure strategies. However, ...
HMBG1 and other soluble factors in HIV-1 pathogenesis
(2009-01-30)
The innate immune system is the first defense mechanism invading
pathogens encounter. Macrophages, dendritic cells and
cytokines/chemokines are important factors for the functionality of the
innate immunity, and provide ...
Role of innate cellular immunity in the immunopathogenesis of HIV-1 infection in Uganda
(2016-11-17)
The global epidemic of HIV has resulted in more than 34 million deaths and currently 36.9 million HIV-infected people worldwide. Uganda has an HIV prevalence of 7.3%, equating to about 1.6 million people. This has placed ...
Paediatric HIV infection in Maputo, Mozambique : horizontal transmission, treatment outcomes and drug resistance
(2010-01-21)
This thesis describes observational studies performed at the main
reference centre for paediatric HIV care and management in Mozambique,
which is one of the countries most strongly affected by the AIDS
pandemic. These ...
Evaluation of HIV testing strategies and monitoring of immune responses in HIV-vaccinated individuals in Tanzania
(2011-09-22)
This thesis describes studies on the evaluation of human immunodeficiency virus (HIV) enzyme-linked immunosorbent assays (ELISAs) and simple rapid HIV assays for use in HIV testing strategies in resource-limited settings ...
Local immune responses in tuberculosis : cytolytic effector functions at the site of mycobacterium tuberculosis infection
(2013-03-22)
Despite recent advances in tuberculosis (TB) research, shortage of knowledge still exists that limits the host-pathogen interactions in human TB. Cell-mediated immunity has been shown to confer protection in TB, although ...
Studies on the host immune response during pulmonary TB and during M.tuberculosis / HIV co-infection
(2012-10-04)
Population studies have shown that HIV-infected individuals co-infected with Mycobacterium tuberculosis (MTB) are at up to 10-fold higher risk of developing active tuberculosis (TB) than their seronegative counterparts. ...