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Role of innate cellular immunity in the immunopathogenesis of HIV-1 infection in Uganda
(2016-11-17)
The global epidemic of HIV has resulted in more than 34 million deaths and currently 36.9 million HIV-infected people worldwide. Uganda has an HIV prevalence of 7.3%, equating to about 1.6 million people. This has placed ...
The role of the tumor suppressor gene, FBW7, and mechanisms of its inactivation in cancer
(2011-05-17)
The F-box protein FBW7 is a tumor suppressor and SCF ubiquitin ligase targeting several key oncoproteins for proteasomal degradation. In this thesis we addressed whether the FBW7 gene is inactivated by mutations in various ...
Characterization of F-box proteins and their target substrates in cancer
(2014-11-11)
Protein degradation, by means of ubiquitylation tagging for subsequent degradation by the ubiquitin-proteasome system (UPS), has opened up a newfound way of protein degradation some three to four decades back. Termed the ...
Aspects of feeding patterns in the first two years of life in Iranian infants
(2011-02-02)
Background: The unique way of providing infants with a perfect nutrition necessary for good growth and development is breastfeeding. Exclusive breastfeeding for the first 6 months is recommended by the World Health ...