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Immune regulation during pulmonary TB and during M. tuberculosis/HIV-1 co-infection
(2013-09-04)
Individually, tuberculosis (TB) and acquired immunodeficiency syndrome (AIDS) pose major global health problems and together, they form a deadly liaison. Preventive vaccines for any of the diseases are not yet available. ...
Studies on the host immune response during pulmonary TB and during M.tuberculosis / HIV co-infection
(2012-10-04)
Population studies have shown that HIV-infected individuals co-infected with Mycobacterium tuberculosis (MTB) are at up to 10-fold higher risk of developing active tuberculosis (TB) than their seronegative counterparts. ...
Impact of Mycobacterium tuberculosis and HIV-1 on innate immune mechanisms
(2012-11-22)
Human immunodeficiency virus type 1 (HIV-1), a causative agent of acquired immunodeficiency syndrome (AIDS), and Mycobacterium tuberculosis (Mtb), a causative agent of tuberculosis (TB), are among the leading causes of ...
Mechanisms influencing natural killer cell recognition of tumour cells
(2016-04-12)
Natural killer (NK) cells are part of our innate immune defence against virus-infected and transformed cells. Through a yet undefined mechanism, expression of inhibitory receptors for self-HLA class I molecules endow NK ...
The role of the ubiquitin-proteasome system in neurodegenerative disorders
(2006-04-28)
Neurodegenerative disorders are a heterogeneous group of clinically and pathologically diverse diseases. The diseases are characterised by selective loss of neurons. in specific regions of the brain. The result is disruption ...
Interactions between neuroblastoma and the immune system : cellular pathways and mediators
(2011-03-04)
Neuroblastoma (NB) is an embryonal tumor of early childhood arising in tissues of the sympathetic nervous system, such as the adrenal gland and paraspinal ganglia. It is the most common extra-cranial solid tumor of childhood, ...