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Paediatric HIV infection in Maputo, Mozambique : horizontal transmission, treatment outcomes and drug resistance
(2010-01-21)
This thesis describes observational studies performed at the main
reference centre for paediatric HIV care and management in Mozambique,
which is one of the countries most strongly affected by the AIDS
pandemic. These ...
Genetic predisposition and dietary factors in relation to adiponectin and insulin resistance
(2013-08-30)
Diabetes mellitus is a global health problem, owing to the high prevalence and enormous associated economic burden. Insulin resistance is a critical condition to the development of type 2 diabetes (T2D). Adiponectin, a ...
Detection and characterization of novel proteins in Trypanosoma cruzi
(2008-04-25)
Trypanosoma cruzi is a flagellated protozoan parasite. It infects a wide range of mammals, including humans. Human T. cruzi infections are endemic to South and Central America. The parasite is transmitted to humans mainly ...
Functional analysis of long non-coding RNAs in cancer
(2017-11-24)
For years the functional role of noncoding RNAs was greatly underestimated. Whole genome RNA sequencing projects that unraveled pervasive transcription emitting from large parts of the human genome changed those perspectives ...
Characterization of non-coding RNAs in cancer
(2014-08-25)
While originally though to only code for proteins, it now stands clear that RNA is a multifunctional molecule involved in a great variety of molecular processes. Recent advances in genome-wide platforms have revealed ...