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Pituitary autoantibodies in endocrine disorders
(2005-09-30)
Autoimmune endocrine disorders are characterised by the development of autoantibodies to specific autoantigens in the target organs. Lymphocytic hypophysitis (LyH) is a disease characterised by inflammation of the pituitary ...
Quality of life in patients with malignant blood disorders : a clinical and methodological study
(2002-10-25)
The overall aim of this thesis was to evaluate and, improve measurements of, health-related quality of life (HRQL) in patients with malignant blood disorders. Patients undergoing autologous stem cell transplantation (SCT), ...
Environmental arsenic exposure in humans : toxicity and adaptation in the Bolivian Andes
(2021-05-07)
Arsenic, a potent toxicant and carcinogen, is naturally present in soil and leaches into groundwater. More than 140 million people worldwide are exposed to arsenic through drinking water. How well humans metabolize arsenic ...
Cytokine-modulated dendritic cell immunotherapy in autoimmune diseases
(2005-01-14)
Autoimmunity is the result of failure of self-tolerance processes. When the immune system fails to differentiate self from foreign, the effector mechanisms are directed towards the individual s own tissues, and pathological ...
Studies on polyomavirus virus-like particles : as vaccines and vectors for immune and gene therapy
(2006-03-10)
Virus-like particles (VLPs) are similar to natural virus particles except that they lack viral genes. They have a similar cellular uptake to the natural virus from which they are derived but are non-infectious and can ...
The role of FPR2/ALX in the vascular wall
(2015-09-24)
Cardiovascular diseases caused by atherosclerosis are a leading cause of mortality worldwide. Inflammation has been described as a key component in the development of atherosclerosis. Lipoxin A4 (LXA4) is a lipid mediator ...
Bis-locked nucleic acids : a new tool for double helix invasion
(2015-08-18)
Deoxyribonucleic acid (DNA) is a macromolecule that contains the information for all living organisms to achieve important cellular processes such as growth and replication. DNA consists of two strands coiled around each ...
Novel treatment of African trypanosomiasis
(2013-01-25)
Human African Trypanosomiasis (HAT) or Sleeping Sickness is fatal if untreated. Current drugs used for the treatment of HAT have difficult treatment regimens and unacceptable toxicity related issues. The effective drugs ...
Measuring health care performance : variations in care process, resource use and outcomes in childbirth care
(2019-02-28)
Introduction: Measurement of health care performance is important for quality assurance and improvement of health services. With regular monitoring and follow-up, unwarranted variations in performance can be reduced. For ...
Acute encephalitis in childhood : clinical characteristics and outcome with special reference to tick-borne encephalitis
(2014-05-05)
Acute encephalitis is relatively uncommon but potentially devastating. The prognosis varies from complete recovery to severe sequelae or death. The diagnosis is difficult to establish and the etiology often remains unclear. ...