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Cytokine-modulated dendritic cell immunotherapy in autoimmune diseases
(2005-01-14)
Autoimmunity is the result of failure of self-tolerance processes. When the immune system fails to differentiate self from foreign, the effector mechanisms are directed towards the individual s own tissues, and pathological ...
Mitochondria, contractility and Ca2+ handling : cardiac and skeletal muscle adaptations in health and disease
(2009-04-29)
Contractility is a fundamental feature of skeletal and cardiac muscles.
An indispensable step in the cellular signal for contraction is a
transient elevation in cytoplasmic free [Ca2+] ([Ca2+]i). Both the
production of ...
Mitochondrial dysfunction in dopamine neurons : implications for Parkinson’s disease
(2012-03-06)
Mitochondria are essential for cellular homeostasis and contain the respiratory chain (RC). Decreased mitochondrial function is associated with ageing, as exemplified by the finding of a mosaic pattern of RC-deficient cells ...
Mechanisms underlying mitochondrial function and biogenesis : implications for type 2 diabetes mellitus and obesity
(2012-12-21)
The ample supply of food, in conjunction with a sedentary lifestyle and certain genetic risk factors contribute to the rise in obesity, insulin resistance and type 2 diabetes mellitus. Reduced mitochondrial capacity for ...