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A multi-omics approach to uncover estrogen receptor (ER) and activator protein 1 (AP-1) signaling networks in breast cancer
(2019-09-27)
Estrogen receptor (ER) binds to DNA indirectly through other transcription factors (e.g. AP-1) to modulate gene expression, which is a tethering mechanism. The ER/AP-1 crosstalk plays an important role in tamoxifen therapy ...
When the bear lost its tail : targeting the GRK/β-arrestins downstream IGF1R in non-epithelial malignancies
(2022-11-25)
Plasma membrane receptors are highly specialized cell surface structures that receive extracellular information and process them into biological responses. Among them, this thesis focuses on two major receptor families: ...
Novel treatment of African trypanosomiasis
(2013-01-25)
Human African Trypanosomiasis (HAT) or Sleeping Sickness is fatal if untreated. Current drugs used for the treatment of HAT have difficult treatment regimens and unacceptable toxicity related issues. The effective drugs ...
Old receptors learn new tricks : biasing anti-IGF1R cancer therapy through the GPCR system
(2022-02-03)
As cancers progress, tumor cells exploit the extracellular signals generated from plasma membrane receptors for cell growth, migration, and anti-apoptosis. G protein-coupled receptors (GPCR) and receptor tyrosine kinases ...
A multi-omics approach to reveal critical mechanisms of activator protein 1 (AP-1) in cancer
(2021-08-24)
Activator protein-1 (AP-1) is a transcriptional factor complex that mainly consists of Fos and Jun family members. Jun proteins can form both homodimers and heterodimers, whereas Fos family members only form heterodimers ...
Investigating the role of p73 proteins in controlling the tumor microenvironment
(2020-10-20)
Cancer is a multifactorial disease governed by oncogenes and tumor suppressors that not only impact on the behavior of the cancer cells but also influence many processes in the surrounding tumor microenvironment. The most ...
Diagnostic and prognostic markers in thyroid carcinoma with focus on TERT activation
(2021-11-25)
Well-differentiated follicular cell-derived thyroid carcinomas are usually categorized into papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC), which represent the most common and second most common ...
Notch signaling requiem : orchestral role of notch signaling in cancer and developmental disease
(2020-08-14)
Notch signaling is an evolutionary conserved contact-dependent cell-cell communication pathway. This “contact” spans from hydra to fruit flies to human; orchestrating development, homeostasis and cancer, thus the Requiem, ...
Targeting MYC and CDK2 in cancer : impacts on senescence, apoptosis and immune modulation
(2021-05-27)
Cancer is a disease in which cells acquire the ability to divide uncontrollably and invade other tissues. An important component of this process is the activation of oncogenes and inactivation of tumor suppressor genes. ...
Targeting glutathione peroxidases : identifying environmental modulators, and screening for novel small molecule inhibitors
(2023-05-22)
Glutathione peroxidases (GPXs) are a family of selenoproteins that are critical regulators of reactive oxygen species (ROS) in the cell, specifically hydroperoxides like hydrogen peroxide (H2O2). ROS are important for ...