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PAK4 signaling in development and cancer
(2019-10-17)
Our understanding of cancer biology has been evolving rapidly shaped by groundbreaking discoveries. We now understand that cancer is not one disease but many, and that tumors are not foreign objects in the human body but ...
Studies on inflammation in atopic keratoconjunctivitis
(2011-11-21)
Atopic keratoconjunctivitis (AKC) is an ocular inflammatory condition associated with atopic dermatitis. AKC is classified as ocular allergy but with features quite different from common seasonal allergic conjunctivitis. ...
Clinical implications of HPV in oropharyngeal cancer
(2012-04-18)
Tonsillar cancer incidence has been increasing in Sweden and many other western countries in the last decades despite that other head and neck cancers are decreasing. It is now established that Human Papillomavirus (HPV) ...
Regulation of non-responsiveness and death in cytotoxic T cells by the agonistic potency of MHC : peptide ligands
(2006-04-21)
CD8+ T lymphocytes are important for immunological control of infections and tumors. The key interaction required to initiate the process of T cell activation is the engagement of the T cell receptor (TCR) with a major ...
Studies on the regulation of hepatic and intestinal lipid metabolism
(2013-09-25)
Disturbances in the lipid homeostasis can result in a wide variety of different diseases and symptoms. This thesis is focused on the regulation of cholesterol metabolism and its relation to atherosclerosis development, and ...
Platelet angiogenic activities and their regulation on endothelial progenitor cell functions
(2015-08-12)
Platelets are essential for haemostasis and thrombosis, but also play a major role in angiogenesis. Activated platelets recruit progenitor cells and induce differentiation into endothelial progenitor cells (EPCs), which ...
From cholesterol to oxidative stress in Alzheimer's disease : a wide perspective on a multifactorial disease
(2008-11-14)
Epidemiological studies have provided evidence that high cholesterol
levels in midlife and lack of antioxidants could render people more
susceptible to develop AD. The aim of this thesis project was to get a
more profound ...
Drug and alcohol induced hepatotoxicity
(2008-05-23)
Drug induced hepatotoxicity is the most common reason cited for withdrawal of already approved drugs from the market and accounts for more than 50 percent of cases of acute liver failure in the United States. Ethanol (EtOH) ...
Effector mechanisms of immunity in atherosclerosis
(2011-12-23)
Atherosclerosis is a disease of the medium and large sized arterial vessels, characterized by cholesterol deposition, inflammation and fibrosis. Low-density lipoprotein (LDL) particles carrying cholesterol are trapped ...
Innate immunity in atherosclerosis : the role of pattern recognition receptors
(2014-10-15)
The pathogenesis of atherosclerosis is greatly influenced by the activities of both innate and adaptive immunity. Danger signals such as cholesterol crystals, oxidized LDL, and modified phospholipids may trigger sterile ...