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From cholesterol to oxidative stress in Alzheimer's disease : a wide perspective on a multifactorial disease
(2008-11-14)
Epidemiological studies have provided evidence that high cholesterol
levels in midlife and lack of antioxidants could render people more
susceptible to develop AD. The aim of this thesis project was to get a
more profound ...
Oral health and behavior in children with attention deficit hyperactivity disorder
(2007-04-20)
Attention deficit hyperactivity disorder (ADHD) is a common developmental
disorder and has a substantial impact on many situations in the child s
daily life. The present thesis investigates the behavior of children with
ADHD ...
Endothelial dysfunction in atherosclerosis and type 2 diabetes : clinical and molecular studies of the role of endothelin and arginase
(2018-05-08)
Background: Atherosclerosis is a modern world scourge and the number of people worldwide diagnosed with type 2 diabetes (T2D) is on the rise, causing much morbidity and mortality. Endothelial dysfunction (ED) is an early ...
Autocrine/paracrine interactions moendocrine pancreasdulating hormone release in the endocrine pancreas
(2007-11-07)
Human islet transplantation is emerging as an alternative to pancreas transplantation or insulin therapy in the treatment of type I diabetes. It has been possible to achieve euglycemia by transplanting isolated human islets ...
Regulation of the ribosomal RNA transcription by c-MYC oncoprotein
(2006-11-30)
The transcription factor c-Myc is a key regulator of growth and proliferation. c-Myc levels are tightly controlled and deregulated c-Myc is often associated with human cancers. In our initial studies we observed that upon ...
Evaluation of Naltrexone as a treatment for amphetamine dependence
(2007-11-27)
Amphetamine addiction is a disease that affects millions of people worldwide and lacks effective treatment. An estimated 35 million persons are reported to abuse amphetamines, which is more than the total number of cocaine ...
Turning understanding into clinical practice : an intervention in continuing professional development based on readiness to change
(2008-08-07)
BACKGROUND: Current continuing medical education (CME) programmes are
often insufficient in changing doctors performance, and there is a need
to improve CME and shift toward a more comprehensive continuing
professional ...
Genetic predisposition and dietary factors in relation to adiponectin and insulin resistance
(2013-08-30)
Diabetes mellitus is a global health problem, owing to the high prevalence and enormous associated economic burden. Insulin resistance is a critical condition to the development of type 2 diabetes (T2D). Adiponectin, a ...
Investigation of hepatocyte signaling pathways in chronic kidney disease : clinical and experimental studies
(2016-05-25)
Chronic kidney disease (CKD) is defined as a loss of renal function from any cause and lasting for more than three months. The CKD phenotype is similar across multiple etiologies, suggesting that renal damage itself is a ...
Cerebrospinal fluid biomarkers in twins with schizophrenia and bipolar disorder
(2015-08-27)
Previously identified cerebrospinal fluid (CSF) biomarkers were studied in 37 twins with
schizophrenia or bipolar disorder to determine their genetic and environmental properties.
Further, comorbidities and sibling risks ...