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Genetic and environmental influences on endometriosis in Swedish twins
(2016-11-10)
Background: Endometriosis is a common gynecological condition with a substantial economic burden on the society. It is known that both genetic and environmental factors are contributing to the phenotypic development of the ...
The fibrinolytic enzyme system : new markers of potential interest in cardiovascular disease
(2005-12-30)
Impaired fibrinolytic function, mainly due to elevated plasma levels of PAI-1, is a common finding in patients with coronary heart disease. Determination or evaluation of the plasma PAI-1 concentrations are complicated, ...
Post-translational modifications in mammary gland development and mammary tumor progression
(2015-10-09)
Breast cancer is one of the most common cancers in women. Estrogen receptor α (ERα)
signaling and p53 signaling have important roles in breast cancer progression. Therefore,
post-translational modifications of ERα and ...
Postmenopausal hormone therapy and cardiovascular risk
(2018-01-09)
Introduction and aims: Postmenopausal hormone therapy (HT) is the most effective treatment for menopausal symptoms, but its safety has been debated during the past 15 years. Previous observational studies showed benefits ...
Post-translational modification of estrogen receptor alpha and p53 in breast cancer cells
(2015-08-21)
Estrogen receptor α (ERα/ESR1) and tumor protein p53 (p53/TP53) signaling are aberrant and play important roles in breast cancer pathogenesis and evolution. ERα is highly expressed in the majority of breast cancers and is ...
Optimization of suicide gene therapy in stem cell transplantation with special reference to the selection marker OuaSelect
(2009-04-22)
For many patients suffering from leukemia and other hematological malignancies, allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative approach. However, an optimal HSCT procedure is yet to ...
Glucose regulation and coronary artery disease : studies on prevalence, recognition and prognostic implications
(2005-05-20)
Coronary artery disease and diabetes mellitus type 2 represent chronic diseases of substantial and growing prevalence. Their coincidence is common, markedly enhancing mortality and morbidity. The risk for cardiovascular ...
Retinoids in the modulation of vascular inflammation
(2004-12-24)
Vascular disease is multifactorial. Smooth muscle cells, the major constituent of the normal vessel wall, play a pivotal role. The pathogenesis includes cellular differentiation, proliferation and inflammatory activation. ...
Studies on neuroimmune interactions in allergic inflammation with focus on neurotrophins
(2006-09-29)
Allergic asthma is a chronic airway disease characterized by an eosinophilic inflammation, bronchoconstriction, increased mucus production and bronchial hyperreactivity. The disease involves several mediators and cell types ...
Genetic and immunological studies of experimental arthritis, with emphasis on a novel C-type lectin receptor gene complex
(2009-03-05)
Rheumatoid Arthritis (RA) is a chronic, systemic autoimmune syndrome primarily affecting peripheral joints. The etiology of RA is largely unknown but complex interactions between genetic and environmental factors contribute ...