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Experimental autoimmune sialadenitis : studies of immunopathogenesis, cellular signaling and MHC genetics
(2001-04-24)
Experimental autoimmune sialadenitis (EAS), an animal model for Sjogren´s
syndrome (SS) in humans, develops spontaneously in certain mouse strains.
A major feature of EAS and SS is infiltration of exocrine glands ...
The fibrinolytic enzyme system : new markers of potential interest in cardiovascular disease
(2005-12-30)
Impaired fibrinolytic function, mainly due to elevated plasma levels of PAI-1, is a common finding in patients with coronary heart disease. Determination or evaluation of the plasma PAI-1 concentrations are complicated, ...
The mouse oocyte as a model in reproductive toxicology studies
(2007-10-18)
It is suspected that certain chemicals may cause alterations in female
reproduction, including ovarian failure and birth defects. Sub-fecundity,
infertility, pregnancy loss, fetal growth retardation, and birth defects
are ...
Platelet dysfunction in diabetes mellitus : impact of hyperglycemia and glycoprotein GPIIb/IIIa inhibition
(2009-02-06)
Diabetes mellitus (DM) is associated with increased cardiovascular
morbidity and mortality, due to diabetic angiopathy. Hyperglycemia is one
of the factors that may cause platelet dysfunction in diabetic patients.
This ...
Cyclophosphamide and treosulfan in the conditioning regimen prior to allogeneic stem cell transplantation
(2011-05-25)
Allogeneic stem cell transplantation (SCT) is a curative treatment for malignant and non-malignant diseases. However, transplantation related morbidity and mortality are major drawbacks affecting the survival and life ...
Sexual violence : epidemiology, treatment and access to health care
(2021-06-01)
Sexual violence is recognized by the World Health Organization as a “… global public health problem of epidemic proportions, requiring urgent action” [1]. In Sweden, the estimated incidence of penetrative sexual violence ...
Exploring the role of PDGF-D in health and disease
(2016-06-01)
The platelet-derived growth factors (PDGF) and their receptors (PDGFRs) regulate growth and migration in cell populations of mesenchymal origin. The PDGF signaling system is vital for development, in neural crest formation, ...
Aspects on the modulation of potassium channels in insulin-producing beta-cells
(2006-10-27)
This thesis attempts to further clarify mechanisms behind the negative effects of overstimulation and the beneficial effect of β-cell rest. For this purpose diazoxide - opener of K+-ATP channels, which reversibly inhibits ...
Molecular genetic studies of oxidative stress related genes
(2005-08-31)
This work has focused on the basal characterisation of transcriptional regulation, including genetic variants, in oxidative stress related genes and the possible impact of such variation in cardiovascular disease. The genes ...
Structural and functional studies of Malassezia sympodialis-derived allergens
(2008-03-21)
Atopic eczema (AE) is a chronic inflammatory skin disease characterised
by pruritic (itchy) skin lesions. The pathogenic mechanisms underlying AE
are still unclear, although several factors such as genetic
predisposition, ...