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Post-translational modification of estrogen receptor alpha and p53 in breast cancer cells
(2015-08-21)
Estrogen receptor α (ERα/ESR1) and tumor protein p53 (p53/TP53) signaling are aberrant and play important roles in breast cancer pathogenesis and evolution. ERα is highly expressed in the majority of breast cancers and is ...
Regulation of mitochondrial gene expression in metazoa
(2013-08-12)
Mitochondria are essential organelles of eukaryotic cells and their main function is to provide the cell with the ubiquitously used energy currency ATP. Impaired energy conversion caused by mitochondrial dysfunction is a ...
Estrogen and liver X receptors in human disease
(2006-11-10)
The nuclear hormone receptors (NRs) are a class of transcription factors that has attracted great interest due to their important roles in animal physiology and metabolism. Studies of knockout (KO) mouse models have indicated ...