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Optimization of suicide gene therapy in stem cell transplantation with special reference to the selection marker OuaSelect
(2009-04-22)
For many patients suffering from leukemia and other hematological malignancies, allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative approach. However, an optimal HSCT procedure is yet to ...
Specific autoimmunity in rheumatoid arthritis : T cells, antibodies and genetic regulation
(2011-05-11)
Complex interactions between genes and environmental factors may result in destruction of the body’s own cells and tissues by the immune system, i.e. autoimmunity. Rheumatoid arthritis (RA) is a chronic joint inflammation ...
Role of genes and environment for the development of rheumatoid arthritis : results from the Swedish EIRA study
(2009-01-09)
Rheumatoid arthritis (RA) is a complex disease with autoimmune features primarily causing destruction in the joints of the body. Knowledge regarding risk indicators and causes are increasing but so far only a few genetic ...
Chronic kidney disease of unknown etiology in Central America and Sri Lanka : renal morphology and clinical characteristics
(2017-09-07)
Background: Chronic kidney disease (CKD) is a global health problem. The most common etiologies of CKD are diabetes mellitus, hypertension, and glomerulonephritis, but over the last several decades a high prevalence of CKD ...