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The diagnostic performance of prostate-specific antigen (PSA) in early detection of prostate cancer : considerations of sensitivity, specificity, lead-time and survival
(2003-09-19)
, or of dying from PC during 20 years of follow-up. In the PSA interval of 3.0-9.9 ng/mL the various estimates of median lead-time obtained ranged from 4.5-11.2 years. Successful screening for PC (i.e., decreased mortality) should be discernible after 6 years...
Diet and risk of acute pancreatitis
(2016-05-11)
Acute pancreatitis is a sudden inflammation of the pancreas. It has a broad spectrum of clinical outcomes, ranging from mild and self-limiting to severe and potentially fatal, and is often followed by recurrent attacks ...
Helicobacter pylori eradication in the Swedish population
(2017-04-28)
Objectives: Helicobacter pylori (H. pylori) is associated with peptic ulcers and gastric cancer and its eradication aims to prevent these conditions. The recommended eradication regimen is triple therapy, consisting of a ...
Calcium dynamics and vesicle-release proteins in a prion-infected neuronal cell line
(2005-03-25)
The prion particle, PrPSc, is an infectious, misfolded form of the cellular prion protein, PrPC that is expressed at high levels in the central nervous system. Prions cause neurodegenerative diseases with clinical signs ...
Utility of hybrid SPECT/CT in sentinel lymph node mapping, and [18]F FDG-PET/CT for treatment response evaluation in cancer patients
(2018-12-21)
The Sentinel Lymph Node Biopsy (SLNB) method is currently well established in the staging of clinically node-negative breast cancer. However, there is some debate concerning the reliability of this method following previous ...
Periodontal conditions and treatment outcomes for subjects with diabetes mellitus : special emphasis on HbA1c levels and T-cells
(2016-11-25)
A two way relationship between periodontal disease (PD) and diabetes mellitus has previously been reported. This thesis was aimed to further analyze the influence of PD on blood glucose levels of subjects with type 2 ...
Evidence-based care of older people : utopia or reality? Healthcare personnel's perceptions of using research in their daily practice
(2007-11-23)
The overall aim of this thesis was to generate knowledge of research utilization of registered nurses (RNs) and other healthcare personnel in the care of older people. The specific objectives for the four included papers ...
Immune dysregulation in early life and risk of autism
(2022-11-15)
Background: The notion of immune perturbations in autism is in part based on numerous observations of an association between maternal infections in general during pregnancy and autism in the child, and on observations of ...
Effects of DNA damage and vesicular exchange in P. falciparum
(2019-05-28)
Plasmodium falciparum causes human malaria and is a global leading cause of mortality from parasitic infections. While decades of concerted effort has yielded significant result in reducing the endemicity, there is evidence ...
Modelling and calculation of DNA damage and repair in mammalian cells induced by ionizing radiation of different quality
(2013-05-21)
Recent experimental data have revealed a wealth of information that provides an exceptional opportunity to construct a mechanistic model of DNA repair. The cellular response to radiation exposure starts with repair of DNA ...