Search
Now showing items 1-10 of 12
Effects of DNA damage and vesicular exchange in P. falciparum
(2019-05-28)
Plasmodium falciparum causes human malaria and is a global leading cause of mortality from parasitic infections. While decades of concerted effort has yielded significant result in reducing the endemicity, there is evidence ...
In silico prediction of CIS-regulatory elements
(2004-04-19)
As one of the most fundamental processes for all life forms, transcriptional regulation remains an intriguing and challenging subject for biomedical research. Experimental efforts towards understanding the regulation of ...
The role of transcriptional repression in Shh signalling and patterning of the ventral neural tube
(2004-05-07)
From flies to humans, members of the Hedgehog (Hh) family of secreted signalling molecules play a vital role in determining cell fate and patterning during embryonic development. In vertebrates, Sonic Hedgehog (Shh) act ...
Mutational analyses of the tumor suppressor gene Patched1 : role in non-melanoma skin cancer and nevoid basal cell carcinoma
(2008-05-02)
Skin cancer is the most common cancer in Western countries, with a
rapidly increasing incidence. The majority of these tumors are
non-melanoma skin cancer (NMSC). The most common NMSC is basal cell
carcinoma (BCC) ...
Genetic analysis of ligand-receptor interactions in the TGF-beta superfamily during early embryonic development
(2006-11-10)
During early development, cells differentiate and acquire specific fates according to their position in concentration gradients of morphogens. These substances often spread from a local region, termed an organizer, and ...
Characterisation of antibiotic-resistant Propionibacterium acnes from acne vulgaris and other diseases
(2006-05-12)
Propionibacterium acnes (P. acnes) is an anaerobic, Gram-positive bacterium that belongs to the normal microflora. The skin is the major habitat but it can also be found in other body regions. P. acnes plays an important ...
Investigating problematic severe asthma in children : a translational approach
(2012-04-18)
Children with problematic severe asthma (PA) have persistent symptoms and/or severe exacerbations despite treatment with high doses of currently available asthma medications. The term PA includes children who are difficult ...
Mitochondrial RNA processing in health and disease
(2021-12-28)
Mitochondria are often described as the powerhouses of the cell, providing the main cellular energy source in the form of adenosine triphosphate. Five enzyme complexes, collectively termed the oxidative phosphorylation ...
Towards understanding of human cytomegalovirus in glioblastoma
(2016-03-21)
Human Cytomegalovirus (HCMV) is a widely prevalent herpesvirus. Following an active
primary infection, often asymptomatic or subclinical in immunocompetent individuals, the
virus establishes latency. HCMV produces several ...
Exosomes : the future of vaccination?
(2011-11-25)
Exosomes are small membrane vesicles that are secreted by cells as means of intercellular communication. They are typically between 50 and 100 nm in diameter and originate from the endosomal compartment of cells. Exosomes ...