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HMGB1 in inflammation : secretion and function
(2008-11-07)
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised
by progressive joint destruction. The inflammatory and joint destructive
processes in RA are mediated by resident synovial cells and cells
recruited ...
Estrogen and liver X receptors in human disease
(2006-11-10)
The nuclear hormone receptors (NRs) are a class of transcription factors that has attracted great interest due to their important roles in animal physiology and metabolism. Studies of knockout (KO) mouse models have indicated ...
Oxysterol receptors LXRs and coregulators in cholesterol metabolism and inflammatory transrepression pathways
(2011-06-08)
The LXRs are important sensors and regulators of cholesterol homeostasis in several metabolic tissues including liver, intestine and macrophages. They regulate target genes involved in cholesterol-, lipid- and carbohydrat ...