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Structural and functional basis of mitochondrial tRNA processing
(2017-11-28)
The mammalian mitochondria are subcellular organelles, generating energy in the cell by the synthesis of adenosine triphosphate (ATP) via oxidative phosphorylation (OXPHOS). The maintenance of proper mitochondrial (mt) ...
Functional genomics of vascular endothelial cells
(2008-10-24)
Angiogenesis, the formation of new blood vessels from preexisting ones, is a process involved in normal development as well as in several pathological conditions, such as cancer, ischemic heart disease, wound healing and ...
Development of PET radioligands synthesized from in-target produced [11C]methane
(2010-02-08)
The aim of this thesis was two-fold. The first aim was to compare the specific radioactivity (SA) of positron emission tomography (PET) radioligands synthesized from in-target produced [11C]methane ([11C]CH4) and [11C]carbon ...
Studies on gamma-secretase activity and products
(2010-02-26)
gamma-Secretase is a transmembrane aspartyl protease involved in processing of a multitude of functionally diverse substrates within their transmembrane domains. gamma-Secretase cleavage of the amyloid precursor protein ...
Molecular studies of the γ-secretase complex : focus on genetic and pharmacological modulation
(2012-09-13)
γ-Secretase is a multi-subunit protease complex, composed of presenilin (PS1 or PS2), Nicastrin, Pen-2 and Aph-1, which generates the Alzheimer disease (AD) related 30-43 amino acid long amyloid β-peptide (Aβ). The complex ...