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Life without mitochondrial DNA : studies of transgenic mice
(2000-11-10)
Mitochondrial DNA (mtDNA) is a closed circular DNA genome that resides in the mitochondrial network. Mutations of mtDNA cause spontaneous and hereditary disorders known as mitochondrial diseases. Mitochondrial transcription ...
Impact of Mycobacterium tuberculosis and HIV-1 on innate immune mechanisms
(2012-11-22)
Human immunodeficiency virus type 1 (HIV-1), a causative agent of acquired immunodeficiency syndrome (AIDS), and Mycobacterium tuberculosis (Mtb), a causative agent of tuberculosis (TB), are among the leading causes of ...
Cancer and migration : epidemiological studies on relationship between country of birth, socio-economic position and cancer
(2010-05-04)
Background: Migrant studies offer a unique opportunity to analyze variation in disease occurrence due to background factors. The role of environmental and lifestyle exposures are of particular interest in cancer research, ...
Studies on the host immune response during pulmonary TB and during M.tuberculosis / HIV co-infection
(2012-10-04)
Population studies have shown that HIV-infected individuals co-infected with Mycobacterium tuberculosis (MTB) are at up to 10-fold higher risk of developing active tuberculosis (TB) than their seronegative counterparts. ...
Insulin-like growth factor-I deficiency, insulin sensitivity, and glucose metabolism
(2013-02-20)
In children and adolescents, growth hormone (GH) and insulin-like growth factor-I (IGF-I) act in concert to stimulate linear growth; however, the effects on glucose metabolism are in opposition. GH increases insulin ...
Immune responses against tumors controlled by the actin cytoskeleton : lessons from primary immunodeficiencies
(2017-10-11)
The actin cytoskeleton and its regulators are vital for cellular processes such as cell motility and immune synapse formation. In this study, the aim was to dissect the role of two of those regulators, WASp and MKL1, in ...
Experimental spinal cord injury : methodological and neuroimmunological contributions with some historical background
(2011-01-19)
Spinal cord injury (SCI) is an incurable neurotraumatic catastrophe that afflicts mostly young individuals with resultant functional impairment of varying degrees of severity. The single pharmacologic treatment option at ...