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Neuronal and endocrine cells' susceptibility to physiologic and toxic stimuli : a study on the effects of steroid hormones
(2000-09-08)
The propensity of a cell to die can be influenced by a number of factors, including hormones, which affect the intracellular and extracellular milieu. The aim of this thesis was to investigate the effects of hormones on ...
Nucleoside analog toxicity and nucleoside kinase deficiency : effects on mitochondrial DNA
(2008-09-05)
Nucleoside analogs are modified nucleosides used in treatment of cancer
and viral infections. They are dependent on intracellular phosphorylation
to be pharmacologically active. Deoxyribonucleoside kinases catalyze ...
Urinary thymine dimer as a biomarker of exposure to ultraviolet radiation
(2013-03-27)
Exposure to ultraviolet radiation (UVR) is associated with all three major forms of skin cancer; squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and cutaneous malignant melanoma (CMM). Different exposure patterns ...
Neuromotor development and brain structure in children born extremely preterm
(2022-11-22)
Children born extremely preterm (EPT) are increasingly surviving but it is well known that they face a high risk of brain injury and neurodevelopmental impairments. The overall aim of the studies included in this thesis ...
Studies of specific immunity against viral infections in patients after stem cell transplantation
(2007-10-12)
Recipients of allogeneic hematopoietic stem cell transplantation
(allo-HSCT) experience a prolonged period of immune deficiency, resulting
in significant morbidity and mortality from the infections. Viruses such
as ...
Investigation of antiviral and anticancer nucleoside analog substrate recognition of drosophila melanogaster and herpes virus deoxyribonucleoside kinases
(2006-09-15)
The deoxyribonucleoside kinase of the fruit fly Drosophila melanogaster (Dm-dNK) is a multisubstrate enzyme that phosphorylates pyrimidine and purine deoxyribonucleosides as well as several anticancer and antiviral nucleoside ...
Functional and genetic studies in type 2 diabetes and obesity
(2013-11-14)
Type 2 diabetes (T2D) and obesity are highly prevalent disorders reflecting a complex interplay of genetics, epigenetics, and environment. They constitute serious health problems and lead to significant morbidity and ...
Early indicators for adverse development of cardiovascular, renal and metabolic function in children born with low birth weight
(2018-08-17)
Prematurity affects more than 10% of infants worldwide and is the main reason for neonatal mortality. Improvements in neonatal care have led to higher survival rates into adulthood. Adverse events during organogenesis and ...
Antibiotic resistance and environmental factors : focusing on the situation in Odisha, India
(2012-05-24)
Background: The rise of antibiotic resistant bacteria is a major challenge to global public health. The environment has a significant impact on health and infectious diseases; however, there is a lacuna of information on ...
Effects of cigarettes, e-cigarettes and Swedish snus on vascular function
(2018-07-17)
Cigarette smoking is considered one of the leading causes of preventable morbidity and premature death worldwide. A large portion of this is attributable to cardiovascular disease such as ischemic heart disease and stroke. ...