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Targeting immune and desmoplastic tumor microenvironment to sensitize gynecological cancer cells to therapy
(2024-01-02)
Cancer is a pervasive global threat that manifests with diverse clinical attributes and notable mortality rates, particularly attributable to its metastatic potential in solid cancers. These tumours encompass various types ...
Functional and genetic studies in type 2 diabetes and obesity
(2013-11-14)
Type 2 diabetes (T2D) and obesity are highly prevalent disorders reflecting a complex interplay of genetics, epigenetics, and environment. They constitute serious health problems and lead to significant morbidity and ...
Atopic dermatitis in adults : epidemiological studies of comorbidity and studies of patients on systemic treatment
(2021-06-01)
Background: Atopic dermatitis (AD) is one of the most common chronic skin disorders globally. It is an itchy inflammatory skin disease that can have a detrimental impact on health-related quality of life. In recent years, ...
Crosstalk between environmental signals and 3d genome organization in the regulation of gene expression
(2021-01-12)
The thesis explores the connection between environmental stimuli and gene expression regulated by the spatial changes in genome organization. In Paper I, by applying state of the art Circular Chromosome Conformation Capture ...
The value of new sonographic modalities, demographic, biometric and proliferative variables for the risk prediction in endometrial cancer
(2020-05-11)
Background: Endometrial cancer is the sixth most common type of cancer among women worldwide and constitutes 4.8% of all cancer in women. The incidence is highest in high-income countries, given how age and obesity are the ...
Artificial intelligence for breast cancer precision pathology
(2022-11-09)
Breast cancer is the most common cancer type in women globally but is associated with a continuous decline in mortality rates. The improved prognosis can be partially attributed to effective treatments developed for subgroups ...