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The road to diagnosis and treatment of patients with lung cancer
(2006-11-27)
Lung cancer is the third most common cancer among men and women in Sweden. More than 3000 persons/year are diagnosed with lung cancer. Despite the presence of many and intense symptoms at diagnosis, most patients still ...
Negative regulation of growth hormone (GH) signaling
(2005-01-14)
Growth Hormone (GH) regulates postnatal longitudinal growth. It also has several other functions. It decreases cholesterol and lipoproteins levels, reduces fat tissue and increases lean body mass. GH actions are mediated ...
Regulators of glucose and lipid metabolism in skeletal muscle and serum : implications for obesity and type 2 diabetes
(2012-11-01)
Type 2 diabetes mellitus (T2DM) has become a growing worldwide problem of public health importance. Insulin resistance is commonly associated with obesity and a key factor mediating the progression to T2DM. The failure of ...
Studies on the mechanisms of action and physiological relevance of SOCS proteins
(2011-10-27)
Understanding systemic biological pathways and the key cellular mechanisms that dictate disease states, drug response, and altered cellular function in metabolic disorders is a significant challenge. Research in the last ...
Central and peripheral mechanisms regulating energy and glucose homeostasis
(2013-05-23)
Obesity is a major health concern across the globe and is often associated with insulin resistance and type 2 diabetes. The coupling of ene rgy intake and expenditure is tightly regulated by central and peripheral mechanisms ...
Gene regulation of acute insulin response in human adipose tissue in obesity and after weight-loss
(2021-09-10)
The incidence and prevalence of obesity and type 2 diabetes is reaching epidemic proportions worldwide and insulin resistance, the pathophysiological link between the two conditions is consequently the focus of intense ...
Beta-arrestins in cancer : linking pro-tumorigenic extracellular activated signaling with the tumor suppressor p53 pathway
(2017-07-25)
The IGF-1R is an important player in cancer development that maintains the malignant phenotype by inducing cell proliferation, survival, transformation, motility and invasiveness. Activation of IGF-R results in its ...
The mechanism of action of SOCS2 and its role in metabolism and growth
(2013-05-23)
A well-known function of Growth Hormone (GH) is the regulation of postnatal longitudinal growth but it also affects other biological processes, for instance metabolism and inflammation. Actions of GH are tightly regulated ...