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Case-crossover studies of the triggering of disease : myocardial infarction and Ménières disease
(2003-05-07)
The general objective of this thesis is to contribute to understanding of the aetiology of myocardial infarction. It focuses on identification and risk-quantification of the factors acting late in the causal chain towards ...
Beta-arrestins in cancer : linking pro-tumorigenic extracellular activated signaling with the tumor suppressor p53 pathway
(2017-07-25)
The IGF-1R is an important player in cancer development that maintains the malignant phenotype by inducing cell proliferation, survival, transformation, motility and invasiveness. Activation of IGF-R results in its ...
Vaccine safety, vaccine effectiveness and other determinants for successful immunisation programmes
(2018-05-11)
The studies in this thesis examined several key determinants for successful uptake of vaccinations in the Nordic countries, with focus on vaccine safety and vaccine effectiveness. In study I, we investigated whether disease ...
Impairment of B cell trafficking and differentiation during HIV-1 infection
(2011-10-05)
During the course of HIV-1 infection, several B cell dysfunctions occur as result of virus replication and indirect mechanisms of immunopathology. The B cells abnormalities include hypergammaglobulinemia, a decreased number ...
HIV-1 infection and loss of serological memory : the role of altered expression of B-cell chemokine receptors, timing of HAART and impaired antibody affinity maturation
(2008-12-26)
Currently, big efforts in HIV-1 research are devoted to the design of a
HIV-1 vaccine. However, no successful vaccine is yet available, also due
to the lack of basic knowledge in HIV-1 pathogenesis which is still
profound. ...
Vascular function in bicuspid aortic valve disease
(2014-10-31)
The aortic valve normally consists of three cusps (tricuspid aortic valve, TAV), but in
0.5-2% of the population it consists of only two cusps (bicuspid aortic valve, BAV),
which is the most common congenital cardiac ...
The role of economic evaluations in health care decision making
(2005-08-19)
Increasing health care expenditures, a rapid introduction of new medical technologies and a need for cost containment policies in most countries during the last decades have led to a growing interest in information from ...
Oral mucositis and periodontal disease in patients with primary or acquired immunodeficiencies
(2013-09-11)
The infection and inflammation in the oral cavity are commonly related to the skewed interaction between host immunity and inhabiting microorganisms. Both primary and acquired immunodeficiency conditions are frequently ...
Morbidity in Ménières disease : aspects on quality of life and triggering factors
(2002-11-22)
Menieres disease is an inner ear disorder of unclear origin, characterized by severe attacks of simultaneously appearing fluctuant hearing loss, vertigo, tinnitus and a feeling of aural fullness. The disease has a well-known ...
Personality in relation to health, psychosocial work environment and occupational health intervention adherence
(2017-11-24)
Background: Personality is a well-studied topic within psychology and it has intrigued scientists and philosophers for centuries. It is a broad, complex and multidimensional phenomenon that constitute individuals’ typical ...