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Negative regulation of growth hormone (GH) signaling
(2005-01-14)
Growth Hormone (GH) regulates postnatal longitudinal growth. It also has several other functions. It decreases cholesterol and lipoproteins levels, reduces fat tissue and increases lean body mass. GH actions are mediated ...
Studies on the activation of cytosolic phospholipase A2 and 15-lipoxygenase-1
(2006-11-28)
Arachidonic acid is a polyunsaturated fatty acid, which has four double bonds and belongs to the omega-6 family of fatty acids. Even if it can be formed in humans from one essential fatty acid, the linoleic acid, most of ...
Experimental studies of N-methyl-D-aspartate receptor NR3 subunits
(2008-04-25)
This thesis focuses on the NR3A and NR3B subunits of the excitatory
glutamate receptor N-methyl-D-aspartate (NMDA). Functional NMDA receptors
are believed to be tetrameric complexes with combinations of NR1 and NR2
subunits, ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Studies on the activation of cytosolic phospholipase A2 and 15-lipoxygenase-1 in hematopoietic cells
(2009-04-08)
Arachidonic acid is a polyunsaturated fatty acid that has four double bonds and belongs to the omega-6 family of fatty acids. Although it can be formed in humans from one essential fatty acid (linoleic acid), most of the ...
Studies on leukotriene B4 and alarmins in inflammatory responses
(2010-01-29)
Leukotriene B4 (LTB4) is a potent proinflammatory lipid mediator that is involved in host defense and inflammatory diseases, such as atherosclerosis. LL-37 and heparin binding protein (HBP) are cationic antimicrobial ...
Idiopathic pulmonary fibrosis : disease presentation, clinical course and potential biomarkers
(2022-05-25)
The interest and research within the area of the fatal lung disease idiopathic pulmonary fibrosis (IPF) has increased exponentially over the past decades. This has resulted in important insights into the nature and ...
Antimicrobial peptides and eicosanoids : roles and interactions in inflammation and host defense
(2017-04-05)
Antimicrobial peptides (AMPs) have a broad spectrum of activities and exert their functions by both direct killing of microbes through the interaction with the microbial membrane, and modulation of innate and adaptive ...
Studies on coactosin-like protein interaction with 5-lipoxygenase
(2009-10-16)
Leukotrienes (LTs) are proinflammatory lipid mediators derived from polyunsaturated arachidonic acid, which is ester-bound at the sn-2 position of glycerol in cellular phospholipid bilayers. In LTs biosynthesis, 5-lipoxygenase ...
MicroRNAs : significance for sensitivity/resistance of lung cancer cells to treatment
(2013-01-24)
Intrinsic or acquired resistance of lung cancer (LC) to chemo- or radiotherapy (CT/RT) limits the treatment effectiveness, which, in turn contributes to tumor progression and ultimately increases the mortality rate of the ...