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Social inequalities in mental health and mortality among refugees and other immigrants to Sweden : epidemiological studies of register data
(2013-02-01)
This thesis aimed to increase knowledge, using population-based registers, of how pre- and post-migration factors and social determinants of health are associated with inequalities in mental health and mortality among ...
Role of membrane associated molecules in liver fibrosis
(2008-03-07)
The aim of the study was to evaluate the role of membrane associated proteins in tissue formation and remodeling, in normal embryogenesis and in liver disease. Molecules associated with cellular membranes provide a ...
Hypothyroidism caused by a mutant thyroid hormone receptor alpha1 : consequences for development and physiology
(2008-01-11)
Lack of sufficient thyroid hormone during pregnancy and early postnatal
development results in profound mental retardation and motor deficits
whereas altered thyroid status in the adult is associated with disturbed
metabolic ...
The role of telomerase reverse transcriptase in human malignancies : genetic polymorphisms and promoter mutations
(2017-09-15)
Telomerase is a ribonucleoprotein with its catalytic subunit telomerase reverse transcriptase (TERT) as a key component, lengthening telomeres. In differentiated human cells, telomerase is silent due to the transcriptional ...
Molecular monitoring of acute graft-versus-host disease after allogenic stem cell transplantation
(2004-08-20)
Acute graft-versus-host disease (GVHD) remains a major barrier to the wider application of allogeneic stem cell transplantation (SCT) for a variety of diseases. GVHD occurs when the transplanted donor Tlymphocytes react ...
The therapeutic potential of ex vivo expanded natural killer (NK) cells for immunotherapy of cancer
(2005-11-18)
Cell and gene therapy of cancers has received much attention in the past decade. A number of applications of cancer treatment have been developed and used. One of the recent applications is immunotherapy of tumours with ...
Regulation of NK cell activity : studies of DAP12-associated receptors in immune synapse formation and in responses to cytomegalovirus infection
(2006-10-27)
Natural killer (NK) cell effector functions are important for innate resistance against tumor cells and viral infections. NK cells display a broad range of inhibitory and activating receptors on the cell surface, which ...
A study on the role of genes of innate immunity in type 1 diabetes
(2010-02-04)
Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing pancreatic beta-cells. It is a polygenic disease in which maximal genetic susceptibility is conferred by the presence of MHC class II genes. ...
Molecular basis for enhanced T-cell recognition and cross-reactivity
(2013-12-20)
T cells of the adaptive immune system recognize and kill infected cells by interacting with pathogenic peptides displayed on major histocompatibility complexes (MHC) through its T-cell receptor (TCR). TCR interactions with ...
Aetiology and infection susceptibility in neutropaenic patients
(2012-04-13)
Increasingly intensive antineoplastic regimes have been effective in the treatment for haematological malignancies, but as effective as it is in limiting neoplasm of the malignant cells, bystander damage occurs equally to ...