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Regulation of NK cell activity : studies of DAP12-associated receptors in immune synapse formation and in responses to cytomegalovirus infection
(2006-10-27)
Natural killer (NK) cell effector functions are important for innate resistance against tumor cells and viral infections. NK cells display a broad range of inhibitory and activating receptors on the cell surface, which ...
Role of AKT/ PKB and 14-3-3 in the regulation of B cell receptor signaling and signalosome assembly
(2015-05-05)
AKT/PKB is an oncogenic serine/threonine kinase regulated via the PI3K pathways. 14-3-3s represent a large group of adaptor proteins that are known to interact with a plethora of signaling proteins and regulate diverse ...
Insulin signaling and glucose transport in insulin resistant human skeletal muscle
(2005-08-19)
Insulin resistance in skeletal muscle is a hallmark feature of Type 2 diabetes mellitus. The overall aim of this thesis was to investigate downstream intermediates in the insulin signaling pathway in an attempt to characterize ...
Molecular dissection of pathways regulating glucose and lipid metabolism using siRNA
(2009-09-04)
Type 2 diabetes is a complex chronic disease that is associated with skeletal muscle insulin resistance. The aim of this thesis is to investigate pathways regulating glucose and lipid metabolism in human skeletal ...