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Pain and sensory function in HIV-infection : with and without antiretroviral therapy
(2000-05-26)
Pain is a common symptom throughout the course of HIV-1 infection, with a prevalence ranging between 30-80%, varying with study methodology and patient selection. Neurogenic pain may appear as a consequence of distal ...
A study on the role of genes of innate immunity in type 1 diabetes
(2010-02-04)
Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing pancreatic beta-cells. It is a polygenic disease in which maximal genetic susceptibility is conferred by the presence of MHC class II genes. ...
Emerging roles of PFKFB3 and CX3CR1 in the DNA damage response and their potential as therapeutic targets in cancer
(2021-06-01)
Genomic instability in cancer is exploited therapeutically using DNA damaging therapies that cause irreparable lesions above the threshold of tolerable DNA damage levels. Nevertheless, toxic side effects on healthy tissues ...