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Hemodynamic optimization in critically ill patients
(2024-02-23)
Background: Intravenous fluids are one of the most common treatments in the health care setting and are usually given in response to hemodynamic instability or shock. However, this rests on the assumption that the cause ...
CYP2C19 and CYP2C9 geno- and phenotypes in healthy Swedish and Korean subjects
(2010-12-23)
Cytochrome P450s (CYPs) are responsible for approximately 75% of the phase I-dependent drug metabolism. Several important polymorphisms in these enzymes are known to affect the individual drug response. CYP2C19 and CYP2C9 ...
Glucocorticoid receptor cross-talk with NF-kappaB and AP-1 : functional role and mechanisms
(2005-03-18)
The protein investigated in this thesis is the glucocorticoid receptor (GR), which is a ligand activated transcription factor that belongs to the superfamily of nuclear hormone receptors. The GR contains three functional ...
Ephrin and Eph-receptor growth factor signaling in non small cell lung cancer : identification of biomarkers and therapeutic targets
(2016-04-29)
Non-small cell lung cancer (NSCLC) is the main subtype of lung cancer (LC) and unfortunately it responds very poorly to conventional chemo- and radiotherapy (RT). Moreover, NSCLC is often diagnosed at a stage where metastases ...
Studies on neuroimmune interactions in allergic inflammation with focus on neurotrophins
(2006-09-29)
Allergic asthma is a chronic airway disease characterized by an eosinophilic inflammation, bronchoconstriction, increased mucus production and bronchial hyperreactivity. The disease involves several mediators and cell types ...
Wnt/beta-catenin signaling in midbrain dopaminergic neurons
(2006-04-07)
Parkinson's disease (PD) is caused by a progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra. However, the mechanisms underlying the degeneration remain elusive and there is no cure for P1) at ...
Early indicators for adverse development of cardiovascular, renal and metabolic function in children born with low birth weight
(2018-08-17)
Prematurity affects more than 10% of infants worldwide and is the main reason for neonatal mortality. Improvements in neonatal care have led to higher survival rates into adulthood. Adverse events during organogenesis and ...
Asthma and allergy in teenagers and young adults, risk-factors and T-cell regulation
(2013-11-15)
Asthma is one of the most common chronic diseases among teenagers and young adults. The prevalence of asthma among young adults in Sweden is approximately 7-10%. Despite this, only a limited number of studies have focused ...
Mechanisms of Wnt signaling : from embryonic stem cells to dopaminergic neurons
(2011-01-19)
The ability of a cell to respond in a specific way to certain signals represents key biological phenomena governing development of multicellular organism. Cellular signaling regulates all aspects of cell biology such as ...
Physical activity, cardiorespiratory fitness, and abdominal obesity in relation to cardiovascular disease risk : epidemiological studies
(2013-10-25)
Although Sweden saw a decline in death rates related to cardiovascular disease (CVD) between 1987 and 2011, it is still the most common cause of death for both women and men. Lifestyle-related factors such as inadequate ...