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Cognitive mechanisms in pain processing : assessed with functional imaging methods
(2002-08-09)
The intensity and unpleasantness of a painful experience is often described as correlating well with the degree of noxious stimulation. However, the perception of pain is not a linear phenomenon, reflecting the signal from ...
Asthma and allergy in teenagers and young adults, risk-factors and T-cell regulation
(2013-11-15)
Asthma is one of the most common chronic diseases among teenagers and young adults. The prevalence of asthma among young adults in Sweden is approximately 7-10%. Despite this, only a limited number of studies have focused ...
Chromatin structure and histone modifications in gene regulation
(2006-11-24)
In the living cell, DNA is densely packed into a chromatin structure constituting nucleosomal arrays. One nucleosome core particle includes a disc shaped protein octamer consisting of pairs of histones H2A, H2B, H3 and H4. ...
In search of diagnostic and prognostic markers for thyroid cancer : a proteomics approach
(2010-04-09)
Early diagnosis of cancer can influence the therapeutic strategy
increasing the chances of cure or, at least, prolonged survival. It is
equally important to be able to detect prognostic signs, i.e. tumor
features that ...
Fission yeast mediator complex and its role in transcriptional regulation
(2011-03-01)
Mediator is an evolutionary conserved co-activator complex that regulates transcription of protein encoding genes in eukaryotes. This multiprotein complex was first identified in budding yeast and shown to be indispensable ...
Chromatin remodelers and their roles in chromatin organization
(2012-11-20)
The DNA in the eukaryotic nucleus is organized into a complex DNA-protein structure called chromatin. The basic repeating unit of chromatin is the nucleosome, which consists of 147 bp of DNA wrapped around a histone protein ...
The CHD chromatin remodeling factors in Schizosaccharomyces pombe
(2007-02-23)
Regulation of chromatin structure is essential in a wide variety of
processes including transcriptional regulation, recombination,
replication, chromosome segregation, development and differentiation. The
enzymes that are ...
Chromatin remodeling and dna topology in transcription and genome stability
(2013-10-25)
Eukaryotic DNA is wrapped around histone proteins to form nucleosomes, the fundamental repeating unit of chromatin. DNA packaging into chromatin both solves and creates problems. It allows the centimeters, or even meters, ...
DNA topoisomerases and nucleosome dynamics in fission yeast
(2015-05-12)
The organization of DNA and associated proteins into chromatin allows for compaction and protection of large eukaryotic genomes. However, it also poses a challenge to fundamental cellular processes such as DNA replication, ...
Interplay of chromatin remodeling, transcriptional regulation, and nuclear organization
(2015-05-12)
Transcription is regulated on different levels to ensure that genes are expressed at the correct time and in the amounts required. At the chromatin level, DNA is wound onto histone proteins, forming nucleosomes that influence ...