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Klara, färdiga, gå : om sjuksköterskors kompetens i övergången mellan grundutbildning och yrkesverksamhet
(2009-08-03)
The transition from nursing student to Registered Nurse (RN) is known to be a stressful period in which the experiences of education encounter the expectancies of the labour market. Previous studies show that the way RNs ...
Optimization of HIV and tuberculosis co-treatment in Tanzanian patients : emphasis on pharmacogenetics and drug interactions
(2013-03-22)
Treatment of HIV and its comorbidities particularly tuberculosis is complicated by wide inter-individual variations in drug exposure due to drug-interactions and variable expressions of drug metabolizing enzymes and ...
Optimization of HIV and tuberculosis co-treatment in Tanzania : drug-drug interactions and clinical outcomes
(2013-02-06)
Background: Sub-Saharan Africa has been greatly affected by the HIV epidemic, with an estimated 23.5 million people living with HIV/AIDS (PLWHA) residing within this region by the end of 2011, being the leading course of ...
Heart failure : advanced treatments and novel hormonal responses
(2014-11-19)
Background: Heart failure (HF) affects 2-3% of the Western population and is associated with a 1 year mortality of 20%. Despite therapeutic advances over the last decades, numerous unanswered questions remain regarding the ...
Improving treatment outcomes for patients with pulmonary tuberculosis in Tanzania : host and pathogen factors
(2017-11-08)
Tuberculosis (TB) causes more than 1.2 million deaths each year globally. Yet, survivors of tuberculosis are left with long term sequelae of chronic inflammatory responses with consequent reduced quality of life. Biomarkers ...
Mammalian thioredoxin reductase as a drug target in anticancer therapy through direct apoptosis induction by selenium compromised forms of the protein
(2006-05-12)
The mammalian thioredoxin system, consisting of thioredoxin(s), thioredoxin reductase(s) and NADPH, participates in the regulation of many important systems in a mammalian cell. The mammalian thioredoxin reductases (TrxR) ...
Exploring thioredoxin reductase as an anticancer drug target
(2009-09-18)
Mammalian thioredoxin reductase (TrxR; EC 1.8.1.9) is a homodimeric NADPH-dependent selenium-containing flavoenzyme with disulfide oxidoreductase activity. The mammalian thioredoxin (Trx) system exerts an impressive spectrum ...
Role of thioredoxin system in cell death caused by toxic compounds
(2014-02-17)
Thioredoxin systems, comprising Trx, TrxR and NADPH, are one of the major disulfide reductase systems, which is crucial in maintaining cellular redox balance in mammalian cells. TrxR is a selenoprotein with a Sec residue ...
Novel combination chemotherapy for treatment and control of schistosomiasis among school children
(2021-05-21)
Despite reported success in reducing severe disease-associated morbidities in endemic countries, praziquantel (PZQ) alone has failed to control and eliminate schistosomiasis, partly due to its poor efficacy against ...
Optimization of pediatrics antiretroviral treatment outcomes among HIV infected children in Ethiopia
(2019-12-11)
Ending the HIV/AIDS epidemic by 2030 is a global agenda. To meet this global goal, having safe and effective antiretroviral therapy is a key requirement. In Ethiopia, the safety and efficacy of combination antiretroviral ...