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Exploring thioredoxin reductase as an anticancer drug target
(2009-09-18)
Mammalian thioredoxin reductase (TrxR; EC 1.8.1.9) is a homodimeric NADPH-dependent selenium-containing flavoenzyme with disulfide oxidoreductase activity. The mammalian thioredoxin (Trx) system exerts an impressive spectrum ...
Participation in everyday occupations and life satisfaction in the stroke-caregiver dyad
(2012-11-05)
In order to develop knowledge that can be used within rehabilitation after stroke, the general aim was to explore participation in everyday occupations and the relation to life satisfaction in persons with stroke and within ...
Small-molecule inhibitors of the receptor tyrosine kinases : promising tools for targeted cancer therapies
(2014-08-11)
Chemotherapeutic and cytotoxic drugs are widely used in the treatment of cancer. In spite of the improvements in the life quality of patients, their effectiveness is compromised by several disadvantages. This represents a ...
Alcohol, tobacco and the risk of LADA-latent autoimmune diabetes in adults
(2016-02-26)
Diabetes is a common and increasing public health problem. Knowledge of risk factors is a prerequisite for efficient prevention; such knowledge is extensive for type 2 diabetes but limited for autoimmune forms of diabetes. ...