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Beyond Th1 and Treg : intestinal T helper cells in disease and tolerance
(2022-08-16)
The human intestinal tract is not only one of the largest organs by surface area in our bodies but also harbors the greatest number of immune cells. These cells are crucial for maintaining tolerance towards the various ...
Understanding allergies : how infections affect the function of T helper cells
(2022-11-24)
Allergic disorders are caused by a combination of hereditary and environmental factors. The hygiene hypothesis postulates that early-life microbial exposures impede the development of subsequent allergic diseases. However, ...
Immune cell composition and cytokine expression in the pregnant and non-pregnant uterus
(2023-05-23)
The success of implantation and further development of the embryo is heavily dependent on the endometrial immune cell composition and its ability to communicate with fetal semi-allogeneic trophoblast cells. Although our ...
Diversity and function of anti-modified protein autoantibodies in rheumatoid arthritis
(2022-11-10)
Rheumatoid arthritis (RA) is a chronic autoimmune disease particularly affecting synovial joints. Anti-citrullinated protein autoantibodies (ACPA) are detected in the serum of about 2/3 of RA patients and are being used ...
Studies on the role of HIF-1 in the control of infection with Mycobacterium tuberculosis
(2022-12-21)
Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis (TB), is responsible for most deaths caused by a bacterium globally. Two main reasons for this are that (Bacille Calmette–Guérin) BCG, the ...
Optimization of HIV and tuberculosis co-treatment in Tanzania : drug-drug interactions and clinical outcomes
(2013-02-06)
Background: Sub-Saharan Africa has been greatly affected by the HIV epidemic, with an estimated 23.5 million people living with HIV/AIDS (PLWHA) residing within this region by the end of 2011, being the leading course of ...
Human innate lymphocytes in host defense, tissue function and reproduction
(2020-10-23)
The immune system is present in all tissues of the human body. In order to respond appropriately to infections, cells of the innate and adaptive immune system work in concert. In this thesis, we focused on natural killer ...
Regulation of vaccine immunity : from myeloid cell functions to antibody responses
(2019-12-05)
The generation of vaccine-induced protection against infections relies on a well-coordinated network of innate immune responses, adaptive cellular responses, and humoral responses. Sufficient stimulation of the innate ...
Clonidine in paediatric anaesthesia : pharmacokinetic and pharmacodynamic aspects
(2002-04-12)
Clonidine is a mixed alpha-2/alpha-1 adrenoceptor agonist. It reduces sympathetic and increases parasympathetic tone which results in a lowering of the baseline blood pressure and heart rate. Descending posjunctional ...
Impact of genetic and environmental factors in intestinal inflammation
(2021-05-07)
The gastrointestinal tract, is continuously exposed to a wide variety of stimuli, including dietary-derived metabolites, environmental compounds and the microbiota. Since these antigens can be beneficial or detrimental for ...