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Improving treatment outcomes for patients with pulmonary tuberculosis in Tanzania : host and pathogen factors
(2017-11-08)
Tuberculosis (TB) causes more than 1.2 million deaths each year globally. Yet, survivors of tuberculosis are left with long term sequelae of chronic inflammatory responses with consequent reduced quality of life. Biomarkers ...
Studies on arachidonic acid metabolism in normal and malignant hematopoietic cells
(2010-01-15)
This thesis deals with the metabolism of arachidonic acid via the 5-lipoxygenase- and the 15-lipoxygenase-1 pathways in normal and malignant hematopoietic cells.
The first part of the thesis (papers I & II) describes ...
Studies on molecular properties and functional regulation of terminal leukotriene C4 synthases and cysteinyl-leukotriene receptor signalling in human endothelium
(2007-03-09)
The transformation of the unstable intermediate leukotriene (LT) A4 into
the glutathione conjugate LTC4, the parent compound of LTD4 and LTE4, is
catalysed by leukotriene C4 synthase (LTC4S) as well as microsomal
glutathione ...
The role of surgeon-performed ultrasound in the management of the acute abdomen
(2008-12-26)
The overall objective of this thesis was to evaluate the effects of bedside surgeon-performed ultrasound on the diagnostic accuracy and management of the patient admitted to the emergency department for abdominal ...
Studies on leukotriene B4 and alarmins in inflammatory responses
(2010-01-29)
Leukotriene B4 (LTB4) is a potent proinflammatory lipid mediator that is involved in host defense and inflammatory diseases, such as atherosclerosis. LL-37 and heparin binding protein (HBP) are cationic antimicrobial ...
Immunity and inflammation in amyotrophic lateral sclerosis : an epidemiological approach
(2021-11-08)
Amyotrophic lateral sclerosis (ALS) is a rare but lethal neurodegenerative disease, characterized by degeneration of both upper and lower motor neurons in the brain and spinal cord. The pathogenesis of ALS is, however, not ...
Studies on the role of NGF in arthritis-induced pain transmission using gait and weight bearing as outcome measures
(2019-10-11)
Pain is one of the most common reasons for seeking healthcare, with approximately forty percent of those suffering from chronic pain having joint pain. Osteoarthritis is the most common cause of joint pain, but currently ...
Leukotrienes and leukotriene receptors : potential roles in cardiovascular diseases
(2007-01-01)
Leukotrienes (LTs) are a family of lipid mediators that are involved in
host defense and inflammatory responses. They are synthesized from
arachidonic acid through the 5-lipoxygenase (5-LO) pathway, and are
divided into ...
Cognitive deficits in alcohol use disorder : etiology and treatment
(2019-11-04)
Alcohol use disorder (AUD) is a psychiatric disorder characterized by a loss of control over drinking, tolerance, withdrawal and negative psychological, physical and social consequences due to excessive alcohol consumption. ...