Search
Now showing items 1-10 of 13
Myocardial infarction and diabetes mellitus : studies on glucose lowering therapies and novel risk markers based on observations from the DIGAMI 2 trial
(2010-05-14)
Background: Patients with myocardial infarction (MI) and type 2 diabetes (T2DM) and
have a poor prognosis. Hyperglycemia is an independent risk predictor.
The best tools for glucose control are debated. Important ...
The insulin-like growth factor system : effects of circulating proteases
(2005-08-18)
The insulin-like growth factor-I and -II (IGF-I/-II) are peptide hormones important for growth and metabolism. They stimulate cell proliferation and differentiation and inhibit apoptosis. In addition, they have insulin-like ...
Novel insulin-like growth factor-binding protein proteases : detection and characterization
(2006-10-07)
Members of the insulin-like growth factor (IGF) system are known to have an impact on cell differentiation, proliferation and survival, and to be important regulators for nutrient metabolism. The IGF-binding proteins ...
Insulin-like growth factor binding protein-3 : structure and function
(2007-11-02)
Insulin-like growth factor (IGF) -I and -II share structural homology with insulin. Their receptors and intracellular signaling are similar. Consequently, the biological actions of IGFs and insulin are overlapping. Insulin ...
Targeting the GH/IGF-1 axis with novel, small molecule inhibitors
(2007-10-05)
The growth hormone (GH) / insulin-like growth factor (IGF) family of
ligands, binding proteins and receptors play multiple roles in cell
growth, metabolism and development. In addition, numerous studies have
demonstrated ...
Regulators of angiogenesis in diabetes and tumors
(2005-11-21)
Angiogenesis is tightly regulated in order to provide adequate supply of nutrients and oxygen for normal cellular function. Tissue oxygenation represents a balance between the requirement for oxygen to maintain the cellular ...
The use of IGF-IR inhibitors in cancer therapy : a potential approach for sensitizing tumor cells to ionizing radiation
(2006-09-15)
This study focused on insulin-like growth factor I receptor (IGF-IR), considered as a promising therapeutic target for cancer treatment. We were in particular interested in the involvement of IGF-IR in tumor cells response ...
Molecular function and targeting of β-arrestins in cancer
(2012-08-22)
In the selection leading to cancer, cancer cells make use of the normal extracellular signaling to gain a growth advantage over normal cells. These signals are, in part, generated by plasma membrane receptors. G Protein ...
From membrane to nucleus : new roles and functions of SUMOylated IGF-1R and EGFR
(2015-03-19)
Cell surface receptor tyrosine kinases (RTKs) role in cell signaling have been studied for decades and their role in cancer progression are undisputable. The insulin-like growth factor 1 receptor, IGF-1R, has been demonstrated ...
IGF-1R inhibition : a tool for functional studies of insulin-like growth factor family in malignant cells
(2006-01-13)
Cancer cells generally posses the capability of overusing normal extracellular signaling for proliferation and/or anti-apoptosis to create growth advantage over the normal cells. Major players in extracellular signaling ...