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IGF-1R inhibition : a tool for functional studies of insulin-like growth factor family in malignant cells
(2006-01-13)
Cancer cells generally posses the capability of overusing normal extracellular signaling for proliferation and/or anti-apoptosis to create growth advantage over the normal cells. Major players in extracellular signaling ...
Biotransformation of the antineoplastic drug oxaliplatin : importance for effects and side effects
(2008-04-04)
Oxaliplatin is a platinum-based cytostatic drug. It is used in
combination with 5-fluorouracil and leucovorin for palliative and
adjuvant treatment of metastatic colorectal cancer. The biotransformation
of oxaliplatin ...
Amount of work : studies on premature death and subjective health in a work life balance perspective
(2006-09-29)
The aim of this thesis is to increase knowledge about the association between amount of work and health. Amount of work is measured as unemployment, excessive work, and interference between work and home. Two studies, based ...
Transarterial chemoembolization in primary liver and kidney malignancies
(2019-03-12)
Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and the most current treatment for unresectable hepatocellular carcinoma is transarterial chemoembolization using drug-eluting beads (DEB-TACE). The ...
Domestic violence during pregnancy in Uganda : the social biomedical consequences and the relationship with induced abortion
(2006-05-05)
Objectives: The specific objectives were to 1) determine the prevalence and predictors of domestic violence during pregnancy; 2) explore community perceptions of factors associated with domestic violence in Wakiso district ...
Modulating the activity of OGG1 using small molecules to target the oxidative DNA damage response in cancer and inflammation
(2021-10-05)
The production of reactive oxygen species (ROS) is increased in several pathological conditions including cancer and inflammation. Multiple lines of evidence suggest that ROS are involved in signaling events that promote ...
Roles of NUDT5 and NUDT15 beyond oxidized nucleotide sanitation and their potential as therapeutic targets
(2018-03-15)
The nucleotide precursor pool is readily susceptible to numerous sources of modification and damage, including alkylation, deamination and oxidation/nitrosylation, among others; most of which have deleterious effects on ...