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The non-human primate as a model of human parkinsonism
(2006-01-06)
The motor deficits seen in Parkinson’s disease (PD) are the result of a loss of catecholaminergic neurons from the substantia nigra (SN) and the associated loss of striatal dopamine. Clinical signs become evident once ...
Targeting the GH/IGF-1 axis with novel, small molecule inhibitors
(2007-10-05)
The growth hormone (GH) / insulin-like growth factor (IGF) family of
ligands, binding proteins and receptors play multiple roles in cell
growth, metabolism and development. In addition, numerous studies have
demonstrated ...
DNA topoisomerases and nucleosome dynamics in fission yeast
(2015-05-12)
The organization of DNA and associated proteins into chromatin allows for compaction and protection of large eukaryotic genomes. However, it also poses a challenge to fundamental cellular processes such as DNA replication, ...
Neurorestorative strategies involving neurogenesis, neuronal precursors and stem cells in animal models of Parkinson's disease
(2009-10-08)
The general aims of the thesis is to provide evidence for neurogenesis in the adult substantia nigra pars compacta (SNpc), where the dopamine-producing neurons lost in Parkinson's disease (PD) reside; to optimize methods ...
Risk characterization of familial cancer using the Swedish family-cancer database with a special reference to breast cancer
(2003-11-07)
This thesis reports on epidemiological studies on family related cancer in Sweden. The Family-Cancer Database was constructed in 1996 from several national registries. Family relations were available from the Generation ...
Post-translational modifications of proteins in human breast cancer : proteomics studies of phosphorylation and nitration and implication of these PTMs in tumorigenesis
(2011-11-11)
Breast cancer is the most common cancer in women. Even though improvements in diagnosis and treatment of breast cancer have been made, it is still the most common cause of cancer death in women. There is a great need to ...
Studies of b-AP15 : a novel inhibitor of proteasome deubiquitinase activity
(2017-04-07)
Bortezomib was the first FDA approved proteasome inhibitor that was initially very successful in treatment of multiple myeloma patients but acquired resistance and adverse side-effect highly decreased patients’ quality of ...
Adenosine receptors and stress : studies using methylmercury, caffeine and hypoxia
(2008-02-21)
Brain development is a precisely organized process that can be disturbed by various stress factors present in the diet (e.g. exposure to xenobiotics) as well as insults such as decreased oxygen supply. The consequent adverse ...
Attention deficit hyperactivity disorder in prison inmates
(2012-05-04)
Background: Attention deficit hyperactivity disorder (ADHD) is an inherited developmental disorder with early onset, chronically persisting in the vast majority of cases. ADHD is associated with pervasive cognitive, emotional ...
Chronic kidney disease : a clinical model of premature vascular aging
(2021-04-27)
Patients with chronic kidney disease (CKD) are prone to develop an accelerated vascular aging phenotype characterized by vascular calcification (VC), a major culprit of cardiovascular complications and premature death. ...