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Exploring the role of PDGF-D in health and disease
(2016-06-01)
The platelet-derived growth factors (PDGF) and their receptors (PDGFRs) regulate growth and migration in cell populations of mesenchymal origin. The PDGF signaling system is vital for development, in neural crest formation, ...
Different approaches to develop radio- and chemotherapy for treatment of human cancer
(2014-09-03)
Despite huge advancements in our knowledge and understanding of the molecular mechanisms of carcinogenesis, the prognoses of many malignant diseases have not improved dramatically. Improvements in the therapeutic efficacy ...
Reducing the morbidity of transurethral resection of the prostate based on patient selection, fluid absorption, and blood loss
(2001-10-05)
A higher long-term mortality due to myocardial infarction after TURP, compared to open surgery, irrigating fluid absorption and blood loss, prompted this investigation of whether prostate size has any correlation with ...
Exploring the role of p73-isoforms during tumor development
(2017-09-28)
The p73 gene was first discovered in 1997 as a family member of p53, and since then this gene has been studied extensively in cancer biology. Among its two main classes of isoforms, TAp73 acts as a tumor suppressor, while ...
Vpu-mediated intracellular targeting of HIV-1 core protein precursor Pr55[gag] and association of Pr55[gag] with lipid microdomains
(2011-10-27)
HIV-1 has been suggested to use lipid rafts for assembly and budding. Lipid rafts can be separated from the bulk membranes by extraction with non-ionic detergents, such as Triton X-100 at cold, followed by a density gradient ...