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Transcriptional regulation by inner nuclear membrane proteins
(2007-04-19)
All cells sense discrete environmental signals and respond by making appropriate adjustments in patterns of gene expression. To achieve this, signaling pathways translate information received at the cell surface into a ...
Medical decision-making in Alzheimer’s disease : a linguistic approach
(2018-10-26)
Objectives. To explore medical decision-making capacity (MDC) for research participation, in patients with Alzheimer's disease, using a linguistic approach and including comparable groups.
Materials and Methods. The ...
Resistance mechanisms for nucleoside analogues : with focus on metabolism and apoptosis
(2002-11-01)
The aim of the thesis was to elucidate the mechanisms underlying resistance to nucleoside analogues used in the treatment of leukemias, with focus on cellular metabolism and induction of apoptosis. Cladribine (CdA), ...
PET studies of the serotonin system in major depression and its treatment
(2014-10-03)
The serotonin system has been implicated in major depression since the
1960s, mainly based on the serotonin enhancing properties of
antidepressants. Positron emission tomography, PET, is the in vivo
molecular imaging ...
PET studies of the serotonin transporter in the human brain
(2006-10-27)
The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and drug treatment of neuropsychiatric disorders. The brain imaging technique Positron Emission Tomography (PET) allows for ...
Dynamic protein trafficking of the nuclear membrane and peroxisomes
(2009-01-30)
The cell nucleus is enclosed by the nuclear envelope (NE), a double lipid membrane separating the nucleoplasm from the cytoplasm. Transport of macromolecules between the nucleus and the cytoplasm takes places through nuclear ...
Uncemented femoral stems : studies on periprosthetic bone remodelling and prevention of bone loss in total hip arthroplasty
(2010-12-02)
Introduction: Tapered uncemented femoral stems are popular implants in total hip arthroplasty (THA). They are easy to use and excellent long-term results have been reported for patients with primary osteoarthritis of the ...
Epidemiological studies on gastroesophageal reflux disease and esophageal cancer
(2022-08-17)
Esophageal cancer is the seventh most common cancer and a lethal malignancy causing a considerably high number of deaths around the world. Despite intensive studies on risk factors associated with esophageal cancer, there ...
A multi-omics approach to uncover estrogen receptor (ER) and activator protein 1 (AP-1) signaling networks in breast cancer
(2019-09-27)
Estrogen receptor (ER) binds to DNA indirectly through other transcription factors (e.g. AP-1) to modulate gene expression, which is a tethering mechanism. The ER/AP-1 crosstalk plays an important role in tamoxifen therapy ...
Characteristics of cytochrome P450-catalysed drug metabolism with focus on a black Tanzanian population
(2003-11-21)
The cytochrome P450 (CYP) enzymes display interindividual and interethnic variability that may alter the disposition of substances metabolised by these enzymes. Both genetic and environmental factors such as concomitant ...