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A multi-omics approach to uncover estrogen receptor (ER) and activator protein 1 (AP-1) signaling networks in breast cancer
(2019-09-27)
Estrogen receptor (ER) binds to DNA indirectly through other transcription factors (e.g. AP-1) to modulate gene expression, which is a tethering mechanism. The ER/AP-1 crosstalk plays an important role in tamoxifen therapy ...
Characterisation of human adipose tissue : ceramide metabolism, depot differences and evaluation of dysfunctionality
(2016-09-26)
Normal adipose tissue function is necessary for maintaining proper energy balance, as both
excess and absence of this tissue lead to metabolic disturbances, such as insulin resistance.
Adipose tissue can be dysfunctional ...
Impact of targeting MYC in metabolic reprogramming and differentiation of cancer
(2022-11-25)
Alterations in several metabolic pathways due to increased energy and biomass demand, as consequence of the uncontrolled proliferation of cancer cells, is known as metabolic reprogramming. Mutations in tumor suppressor ...