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Resistance mechanisms for nucleoside analogues : with focus on metabolism and apoptosis
(2002-11-01)
The aim of the thesis was to elucidate the mechanisms underlying resistance to nucleoside analogues used in the treatment of leukemias, with focus on cellular metabolism and induction of apoptosis. Cladribine (CdA), ...
Characterization of ERp29 : a novel secretion factor of endoplasmic reticulum
(2005-04-29)
ERp29 is a ubiquitously expressed endoplasmic reticulum protein strongly
conserved in mammalian species. The N-terminal domain of ERp29 is similar
to the thioredoxin domain of protein disulfide isomerase (PDI) lacking
however ...
Complications after total hip arthroplasty : register-based studies on surgical approach and infections
(2014-10-24)
Background: The often excellent outcome of total hip arthroplasty (THA) is sometimes compromised by prosthesis related complications. There is an ongoing debate regarding the effect of surgical approach on prosthesis related ...
Paediatric burn injuries in Cape Town, South Africa : context, circumstances, and prevention barriers
(2007-05-03)
Despite concerns about the impact of childhood burns, there remains a
paucity of systematic descriptions of its epidemiology, contexts of
occurrence, and preventability. This information is essential for the
development ...