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Nursing interventions in radiation therapy : studies on women with breast cancer
(2000-02-11)
The general aim of this thesis was to acquire knowledge to be used to improve the care of cancer patients during and after radiation therapy, in particular for women with breast cancer. The specific objectives were first ...
Pneumococcal pili and other cell surface properties affect the infection biology of Streptococcus pneumoniae
(2007-04-13)
The pneumococcus, Streptococcus pneumoniae, is a major respiratory tract
disease causing pathogen with an estimated mortality of 1-2 million per
year worldwide. It is the most common bacterial cause of sinusitis,
otitis ...
Fractures of the distal radius : epidemiology, treatment and outcome assessment
(2013-04-16)
This thesis aims to increase scientific knowledge of the most common fracture, namely the distal radius. Our understanding of this fracture is still limited, but every year in Sweden over 20,000 patients suffer from this ...
Demand and capacity imbalance in the emergency department, and patient outcomes
(2021-02-16)
Background: An emergency department (ED) is always open and continuously needs to balance the inflow and demand for emergency service with available capacity. When demand exceeds the available capacity of an ED, it is ...
Human muscle response to sprint exercise and nutrient supply with focus on factors related to protein metabolism
(2016-12-21)
The overall aim of the present thesis was to study the muscular response to repeated bouts of 30-s sprint exercise. This type of exercise gives rise to a profound metabolic perturbation that might counteract an exercise-induced ...
Markers of differentiation and prognosis in prostate cancer : a morphological and immunohistochemical study
(2008-03-28)
Prostate cancer (PCa) is the most common malignancy in men worldwide. The
disease shows a wide range of patient outcome between indolent and highly
aggressive tumor behavior. Prognostic factors are needed to stratify ...
The role of the RNA-binding protein Wig-1 in post-transcriptional regulation of gene expression
(2014-10-17)
The p53 transcription factor is activated by cellular stress. This triggers transcriptional activation of a number of p53 target genes, leading to responses such as cell cycle arrest and/or induction of apoptosis. Wig-1 ...
Identification of genes that regulate arthritis and IgE production in rat and human
(2005-08-08)
Multiple genome-wide scans have identified quantitative trait loci (QTLs) that influence inflammatory diseases on chromosome 4q42 in DA rats. Several of the QTLs overlap with the QTL designated Oia2 (Oil-induced arthritis-2), ...
Molecular characterization of apoptosis in B-cell chronic lymphocytic leukemia
(2005-03-18)
B-cell chronic lymphocytic leukemia (B-CLL), characterized by an accumulation of monclonal B cells, is the most common adult leukemia in the Western world. Defective apoptosis is considered to contribute to cell accumulation, ...
Novel biomarkers in regulating human dense connective tissue repair
(2022-11-18)
Painful and degenerative disorders of the musculoskeletal system pose a tremendous burden on the healthcare system. One main reason is the limited knowledge of the underlying key factors and pathways responsible for the ...