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Demand and capacity imbalance in the emergency department, and patient outcomes
(2021-02-16)
Background: An emergency department (ED) is always open and continuously needs to balance the inflow and demand for emergency service with available capacity. When demand exceeds the available capacity of an ED, it is ...
Eosinophilic dermatosis implications of skin-commensal bacteria and antimicrobial peptides and proteins at birth
(2009-08-28)
At birth, the newborn infant is transferred from a sterile life in utero to an earthly life in coexistence with microbes. This transition includes the potential danger of a microbial invasion through the epithelial linings, ...
Studies of the device perfect capsule in an animal model to reduce lens epithelial cell proliferation
(2008-09-12)
The sealed-capsule irrigation device, the Perfect Capsule, is a surgical
device designed to target lens epithelial cells (LECs) during cataract
surgery and prevent posterior capsule opacification (PCO). This is
especially ...
Leukocyte activation in newborns in relation to prenatal stress
(2009-11-05)
The aim of this project is to describe the pattern of innate immunity responses at birth with focus on the recruitment of leukocytes such as eosinophils and neutrophils and their content of cathelicidin antimicrobial peptide ...
Nucleoside analog toxicity and nucleoside kinase deficiency : effects on mitochondrial DNA
(2008-09-05)
Nucleoside analogs are modified nucleosides used in treatment of cancer
and viral infections. They are dependent on intracellular phosphorylation
to be pharmacologically active. Deoxyribonucleoside kinases catalyze ...
The small bowel and functional dyspepsia : peptide hormones and neurotransmitters
(2013-11-15)
Functional dyspepsia (FD) is believed to be caused by pathophysiological changes in the upper gut. Gastro-intestinal motility, epithelial transport and signalling is associated with the metabolism of nutrients and the ...
Resistance mechanisms for nucleoside analogues : with focus on metabolism and apoptosis
(2002-11-01)
The aim of the thesis was to elucidate the mechanisms underlying resistance to nucleoside analogues used in the treatment of leukemias, with focus on cellular metabolism and induction of apoptosis. Cladribine (CdA), ...
Modelling ineffective erythropoiesis in myelodysplastic syndromes with ring sideroblasts
(2019-10-02)
Myelodysplastic syndromes with ring sideroblast (MDS-RS) is a clonal hematological malignancy characterized by accumulation of iron filled erythroblasts called ring sideroblasts in the bone marrow, and recurrent somatic ...
Immunological consequences of Epstein-Barr virus replication
(2008-04-04)
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus involved in
the pathogenesis of a wide spectrum of malignant and non-malignant
diseases. In healthy EBV carriers, the virus is believed to infect two
major ...
Varicella immunity and vaccination
(2008-01-04)
Varicella-zoster virus (VZV) is an air-borne, extremely contagious herpesvirus. It causes chickenpox, which usually is a benign illness in childhood. Adults, pregnant women and immunocompromised patients often get a severe ...