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The role of the RNA-binding protein Wig-1 in post-transcriptional regulation of gene expression
(2014-10-17)
The p53 transcription factor is activated by cellular stress. This triggers transcriptional activation of a number of p53 target genes, leading to responses such as cell cycle arrest and/or induction of apoptosis. Wig-1 ...
Pediatric obstructive sleep apnea : evaluation of questionnaire and surgical treatment
(2017-02-23)
Obstructive sleep apnea (OSA) is a major pediatric health problem and is associated with potentially severe consequences if left untreated. Diagnosing OSA in children can be challenging since the clinical symptoms are very ...
Immunological recognition and tumor escape mechanisms of ovarian carcinoma
(2006-09-22)
Ovarian carcinoma is a leading cause of cancer mortality and there is an urgent need for new and better therapeutic modalities that result in improved long-term outcome for this severe malignancy. One promising treatment ...
Intratumoral heterogeneity in glioblastoma: subtype transition and cell-to-cell communication
(2020-08-06)
Glioblastoma is a most aggressive brain tumor with a median overall survival of less than two years. The current treatment is surgery, chemotherapy, and radiotherapy. However, glioblastoma is difficult to treat and recurs ...