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The p53-induced Wig-1 protein : studies of interaction partners and expression in tumor cells
(2008-09-04)
The tumor suppressor p53 is a critical regulator of life and death in
cells. The p53 protein is present at very low levels in cells under
normal conditions but accumulates in response to different stress
stimuli, such ...
Microglia in the juvenile brain after cranial irradiation
(2019-12-19)
Radiotherapy is used to treat pediatric brain tumors and is often accompanied with debilitating late effects, such as cognitive decline. However, the mechanisms are poorly understood, and consequently there is still no ...
Occupational factors and risk of rheumatoid arthritis : studies on silica, physical workload and cold work environment
(2017-11-21)
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease that could lead to joint destruction and disabilities. Around 30-70 million people worldwide are affected by RA. Both genetic and environmental factors ...
On HIV-1 restriction in human dendritic cells and peripheral blood mononuclear cells
(2011-12-16)
Dendritic cells (DCs) are one of the first cells to encounter HIV-1 during sexual transmission. They may transmit the virus to CD4+ T-cells either locally or in the draining lymph nodes. In the present work, we have focused ...
Understanding ageing : the role of mitochondria in determination of caenorhabditis elegans life span
(2011-08-23)
Mitochondria are organelles found in eukaryotic cells. They are involved in many
vital cellular functions. Consequently, mitochondrial dysfunction leads to a variety of human disorders. Many studies of the last 50 years ...
The role of adjuvant-induced innate immune activation in shaping vaccine responses
(2018-09-27)
Adjuvants are components added to non-live vaccine formulations to enhance the effect of the vaccine by alerting the immune system to initiate a response against the vaccine. Powerful new adjuvants will be critical for the ...
Dendritic cell responses to apoptotic cells : is there life after death?
(2010-05-07)
Dendritic cells (DC) are antigen-presenting cells that are crucial for
the induction of immune responses to pathogens and for the maintenance of
self-tolerance. DCs efficiently capture and process material from their
local ...
B cell transcriptomics and immunoglobulin genetics in rheumatoid arthritis
(2022-11-02)
Rheumatoid Arthritis (RA) is a complex autoimmune disease characterized by inflammation of the peripheral joints. The exact disease pathology remains to be elucidated, but it has been hypothesized that autoreactive B cells ...
Immune responses against tumors controlled by the actin cytoskeleton : lessons from primary immunodeficiencies
(2017-10-11)
The actin cytoskeleton and its regulators are vital for cellular processes such as cell motility and immune synapse formation. In this study, the aim was to dissect the role of two of those regulators, WASp and MKL1, in ...