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Region-specific expression of the interleukin-1 system in rat brain following endotoxin challenge and excitotoxic neurodegeneration
(2000-01-28)
Traditionally, up-regulation and secretion of cytokines are associated with peripheral immune and inflammatory responses. There is now evidence that cytokines also exert various actions in the central nervous system (CNS). ...
Neuropeptides and spinal antinociception : studies on galanin, nociceptin and endomorphin
(2003-05-29)
Nociception and/or the sensation of pain is essential for the survival of the organism. Just as important are the antinociceptive mechanisms that reduce the nociceptive input and perceived pain. Without such mechanisms, ...
HCMV-induced epigenetic alterations : a novel pathway to CNS tumors?
(2018-06-01)
Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented ...
Regenerating the brain : stem cell differentiation and cholinergic dysfunction in Alzheimer disease
(2014-05-15)
Hippocampal neurogenesis in the adult brain is important for learning and memory processes, which are heavily affected in Alzheimer disease (AD). Thus, targeting processes that could stimulate neurogenesis is a logical ...
Cured but not well : long term survivorship after allogeneic haematopoietic stem cell transplantation
(2022-05-11)
Improved donor matching and supportive care have reduced short term complications after allogeneic haematopoietic stem cell transplantation (HSCT), leading to a growing number of survivors. However, despite being cured of ...
Apolipoprotein E and cholinergic enzymes : the interface in dementia
(2017-02-10)
The main confirmed genetic risk factor for sporadic form of Alzheimer’s disease (AD) is apolipoprotein E (ApoE) ε4 allele (APOE4). ApoE protein aids in receptor ligand mediated transport, distribution and metabolism of ...
Mechanisms of Wnt signaling : from embryonic stem cells to dopaminergic neurons
(2011-01-19)
The ability of a cell to respond in a specific way to certain signals represents key biological phenomena governing development of multicellular organism. Cellular signaling regulates all aspects of cell biology such as ...