Search
Now showing items 1-10 of 80
Genome-wide study of HDACs and transcription in Schizosaccharomyces pombe
(2010-05-27)
The eukaryotic genome has to be organized to fit into the cell and this is achieved by packing of DNA into chromatin. The basic repeating structural unit of chromatin is the nucleosome, which consists of DNA wrapped around ...
Regulation of striated muscle contraction
(2008-08-28)
Background and Aims: Muscle contraction involves cross-bridge interaction between actin and myosin filaments, which is regulated by variations of intracellular [Ca2+] and influenced by several external control systems. To ...
Genetic, epigenetic and environmental factors of importance for CYP1A2 catalyzed drug metabolism
(2008-11-14)
The heme containing cytochrome P450 (CYP450) enzymes participate in the phase I metabolism of drugs and other xenobiotics as well as endogenous substrates. CYP1A2 is one of the major CYP450 enzymes and account for about ...
Aspects on latency in HIV-1 infection
(2010-04-16)
The use of combination antiretroviral therapy (ART) has resulted in a substantial reduction in viremia, a rebound of CD4+ T-cells and increased survival for human immunodeficiency virus type 1 (HIV-1) infected individuals. ...
Traffic noise and cardiovascular disease
(2010-04-30)
Traffic noise is an increasing problem in urban areas worldwide, but health effects in relation to traffic noise exposure are not well understood. Several studies show that noise may give rise to acute stress reactions, ...
Sox proteins and neurogenesis
(2010-04-02)
The primordium of the central nervous system is specified in a process called neural induction at which point the ectoderm is subdivided into the epidermal ectoderm and the neural plate. With time the neural plate will ...
NK cell and dendritic cell interactions in innate immune responses
(2009-04-24)
Natural killer (NK) cells are cytotoxic cells of the innate immune
system. They have been found to be critical in the defense against
infections and also against some tumors. Recent studies have shown that
NK cells ...
Mutations and molecular signatures in human melanoma
(2010-02-05)
Cutaneous melanoma is a disease which results from a complex mixture of various extrinsic and intrinsic factors, with some major players still unknown. Although primary tumors are highly curable with surgical excision, ...
The human gastric microbiota in health and disease
(2010-04-16)
The human body comprises of complex microbial ecosystems that have co-evolved with its host and play important roles in the maintenance of health and in the etiology and outcome of various disease states. The microbiota ...
Dissemination of Toxoplasma gondii to the central nervous system : with special reference to in vivo bioluminescence imaging
(2009-08-07)
Toxoplasma gondii causes an asymtomatic chronic infection in immune
competent individuals that can be life-threatening in individuals that
become immuno-compromised or to the developing fetus. This thesis aimed
to (1) ...