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Use of microbiomics to study human impacts on complex microbial communities
(2006-11-24)
The study of bacterial communities in nature is currently a challenge. The majority of bacteria in clinical and environmental samples have not yet been cultured and therefore we cannot fully understand their roles in nature ...
NK cell and dendritic cell interactions in innate immune responses
(2009-04-24)
Natural killer (NK) cells are cytotoxic cells of the innate immune
system. They have been found to be critical in the defense against
infections and also against some tumors. Recent studies have shown that
NK cells ...
Glucocorticoid receptor cross-talk with NF-kappaB and AP-1 : functional role and mechanisms
(2005-03-18)
The protein investigated in this thesis is the glucocorticoid receptor (GR), which is a ligand activated transcription factor that belongs to the superfamily of nuclear hormone receptors. The GR contains three functional ...
Health effects of snus use : cardiovascular diseases, weight gain and obesity
(2012-11-08)
Use of snus is most prevalent in Nordic countries, and especially in Sweden, where 18% of men and 3% of women are daily users. Snus is also used to a minor extent in the United States where an increasing interest is seen ...
Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs
(2014-05-19)
Chemotherapeutic agents have become widely applied for treatment of various types of malignancies. Drug resistance unfortunately remains as a major obstacle for the effectiveness of chemotherapy. Cancer drug resistance ...
Low back and neck-shoulder pain : work and heritability
(2008-11-14)
Low back pain (LBP) and neck-shoulder pain (NSP) represent a large public
health problem being common disorders that often lead to negative
consequences for the individual and large costs for Society. The main
goal of ...
Concepts in DNA immunization overcoming viral diversity and enhancing plasmid immunogenicity
(2004-05-07)
On April 23, 1984, the prominent scientist Robert Gallo held a historical press conference at the Department of Health and Human Services, Washington D.C., USA. He announced that his laboratory at the National Institutes ...
Stimulating neuroprotective and regenerative mechanisms in Alzheimer disease
(2013-08-14)
The processes involved in neuroprotection and brain repair are an important aspect of the preservation and restoration of neuronal functions affected by pathological lesions. Mechanisms that stimulate, manage and regulate ...
Unraveling pathogenic proteins and pathways in Alzheimer disease : a focus on proteomics
(2020-11-05)
Alzheimer disease (AD) is a multifactorial and complex neurodegenerative disorder. To date, different mechanisms, such as impairment of synaptic, mitochondrial and autophagic function, neuroinflammation and many more, are ...
Therapeutic potential of extracellular vesicles
(2017-11-15)
Extracellular vesicles (EVs) are nanometer-sized, lipid membrane enclosed, vesicles that are secreted by most, if not all, cells and contain macromolecular material of the source cell including lipids, proteins and various ...