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Heritability and sex differences in experimental neuropathic pain with special emphasis on the role of the major histocompatibility complex
(2008-11-21)
Neuropathic pain caused by injury to the nervous system is a difficult clinical problem and a large proportion of patients experience no or only partial relief from existing treatments. Pain sensitivity and the development ...
The role of the microenvironment on the regulation of Epstein-Barr virus latent gene expression
(2009-05-15)
expression in this EBV-converted subline. In this system we identified two cytokines, IL-4 and IL-13, that could modulate the viral gene expression (specifically, induce the expression of LMP-1) and with their help we could for the first time reconstitute...
Task-shifting of major surgery to midlevel providers of health care in Mozambique and Tanzania : a solution to the crisis in human resources to enhance maternal and neonatal survival
(2010-03-05)
Background: Task-shifting, using non-physician clinicians (NPCs) to
perform major surgery in obstetric emergencies is common, though still
controversial, in Africa to overcome the crisis of human resources for
health. ...
Molecular dynamics of protein-nucleic acid complexes
(2010-04-16)
Nucleic acids are essential molecules when it comes to replication, transcription and translation of the genetic information and nearly all functions of nucleic acids are carried out in complex with proteins. The proteins ...
Biosynthesis and biological role of leukotrienes in human lymphocytes
(2009-04-09)
Leukotrienes (LT) are biologically active metabolites of arachidonic acid. The key enzyme in leukotriene biosynthesis is 5-lipoxygenase (5-LO). Leukotriene B4 exerts its biological effect mainly via BLT1, the high affinity receptor for LTB4...
Genetic and immunological mechanisms regulating neuroinflammation
(2010-10-27)
Multiple sclerosis (MS) is the most common neurological disorder in young adults and imposes both health and socioeconomic burdens on society. The cause and aetiology of MS are incompletely understood and current treatments ...
Influence of renal dysfunction on therapy and prognosis in patients with myocardial infarction
(2010-04-30)
The aim of this thesis is to evaluate the influence of renal dysfunction on the presentation for myocardial infarction (MI), its treatment and outcome. Patients between 2003 and 2006 were selected from the nationwide Swedish ...
Genetic content of clinical pneumococcal isolates and its relation to disease outcome
(2009-09-30)
with serotype 1, 4, 7F having a high invasive disease potential and 6A, 19F and 23 F having a low invasive disease potential. We did, however, find differences between clonal types of the same serotype, for serotypes 14 and 6B. We further investigated 6B...
A study on the role of genes of innate immunity in type 1 diabetes
(2010-02-04)
against islet cell antigens and mononuclear cell infiltrates, especially CD4+ and CD8+ T cells, are characteristic of the disease. Recent evidence suggests innate immunity may be involved in the disease pathogenesis. The aim of this thesis is to identify...
Amoebiasis : diagnosis and prevalence in León Nicaragua
(2009-05-04)
About ten yearly cases of liver abscess are presented in University
Hospital, León, Nicaragua. Based on serology most of them have been shown
to be amoebiasis cases. This raised the question of Entameoba histolytica
prevalence ...