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Molecular dynamics of protein-nucleic acid complexes
(2010-04-16)
Nucleic acids are essential molecules when it comes to replication, transcription and translation of the genetic information and nearly all functions of nucleic acids are carried out in complex with proteins. The proteins ...
Studies on sterol 27-hydroxylase (CYP27A1)
(2004-01-30)
Human sterol 27-hydroxylase (CYP27A1) has been studied in the present thesis with focus on substrate specificity and possible role of the enzyme for prevention of accumulation of cholesterol and cholestanol in tissues. ...
Estrogen and liver X receptors in human disease
(2006-11-10)
The nuclear hormone receptors (NRs) are a class of transcription factors that has attracted great interest due to their important roles in animal physiology and metabolism. Studies of knockout (KO) mouse models have indicated ...