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Body perception and brain plasticity in blind and sighted individuals
(2023-04-28)
Lack of vision is associated with large-scale brain plasticity. Vision, touch, proprioception, interoception, and other sensory modalities are thought to play a vital role in developing and maintaining bodily awareness. ...
Metabolism and neural differentiation in childhood neuroblastoma
(2017-05-19)
Neuroblastoma is the most common and aggressive extracranial solid tumor during childhood. MYCN-amplification is found in approximately 25 % of all neuroblastoma cases, and is defined as high-risk disease. Development of ...
Role of c-Myc in the regulation of rDNA transcription by RNA polymerase I
(2010-04-30)
Ribosomal biogenesis and protein translation are finely coordinated with cell proliferation. All three RNA polymerases Pol I, II, and III are utilized for highly efficient and accurate ribosome production. The transcriptional ...
Structure and function in c-Myc and Grx4 : two key proteins involved in transcriptional activation and oxidative stress
(2006-11-24)
The proto-oncogene c-myc is critical for growth and development and deregulation of c-myc expression affects the initiation and expansion of a wide range of human cancers, many of them aggressive. cMyc is a multi-domain ...
Pro-senescence therapy by targeting MYC and its network as a strategy to combat cancer
(2019-03-26)
Cancer is defined as abnormal cell proliferation with the potential of metastasis and is an increasing threat to global health as the population becomes older. Cancer is triggered by gain-of-function mutations in oncogenes ...