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Structure and function in c-Myc and Grx4 : two key proteins involved in transcriptional activation and oxidative stress
(2006-11-24)
The proto-oncogene c-myc is critical for growth and development and deregulation of c-myc expression affects the initiation and expansion of a wide range of human cancers, many of them aggressive. cMyc is a multi-domain ...
Studies on bone and mineral disorders in CKD : determinants and survival implications
(2013-11-20)
Disruptions in mineral metabolism occur already at an early stage of chronic kidney disease (CKD) and may eventually lead to a complex of CKD - mineral and bone disorders (CKD-MBD) characterized by alterations of the mass, ...
Cell wall remodeling proteins in Mycobacterium tuberculosis : structure, function and inhibition
(2017-10-27)
The complex and peculiar cell wall architecture is vital for the survival of M. tuberculosis in the host and therefore an established target for several currently used drugs. Understanding of the cell wall maintenance and ...
Structural basis of cysteine biosynthesis and peptidoglycan remodelling in Mycobacterium tuberculosis
(2013-12-12)
Mycobacterium tuberculosis is the causative agent of tuberculosis, which is responsible for 1.3 million deaths annually. Treatment is difficult due to an elaborate defense machinery, which includes specific metabolic changes ...
Targeting MTHFD1 and MTHFD2 as cancer treatment
(2023-09-18)
One-carbon (1C) metabolism provides building blocks for nucleotide synthesis and
therefore plays a central role in DNA replication and repair. To sustain rapid proliferation,
cancer cells often upregulate their 1C ...